인돌유도체.I, 1-Benzylindole-3-aceto-phenone 유도체에 대한 Thiourea의 친핵성 첨가반응 메카니즘과 그 반응속도론적 연구

• 영문명: Indole Derivatives I, The Kinetics and Mechanism of the Nucleopilic Addition of Thiourea to 1-Benzylindole-3-Acetophenone
• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: 이기창(Lee Ki Chang) 황성규(Hwang Sung Kwu) 류정욱(Ryu Jung Wook) 황용현(Hwang Young Hyun) 성기천(Sung Ki Chun)
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제8권 제2호, 175~181쪽, 전체 7쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 1991.11.30

영문 초록

The kinetics of the addition of 1-benzylindole-3-(p-substituted) acetophenone derivatives was investigated by ultraviolet spectrophotometery in 30% dioxane -H₂O at 25℃. A rate equation which can be applied over wide pH range was obtained. The Substituent effects on 1-benzylindole-3-(p-substituted) acetophenone derivatives were studied, and addition were facilitated by electron attracting groups. On the base of the rate equation, substituent effect, and general base effect the plausible addition mechanism was proposed: Below pH 3.0, only neutral thiourea molecule was added to the carbon-carbon double bond, and in the range of pH 0.0~14.0, netural thiourea molecule and thiourea anion competitively attacted the double bond. By contrast, above pH 10.0, the reaction was dependent upon only the addition of thiourea anion.

목차

ABSTRACT

I. 서론

II. 실험

III. 결과 및 고찰

IV. 결론

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