랫드의 신경조직에 미치는 Tellurium의 독성에 관한 연구

• 영문명: A Study on the Neurotoxic Effects of Tellurium on Murine Nervous System
• 발행기관: 한국환경보건학회
• 저자명: 김기석 정문호
• 간행물 정보: 『1. 한국환경보건학회지』제24권 제3호, 35~40쪽, 전체 6쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 1998.09.30

영문 초록

This study was conducted to examine the pathological changes of rat peripheral nervous system during exposure to tellurium known to be a demyelinating agent by using teasing nerve fiber method and quantitative light microscopic analysis by image analyzer. The pellet containing 1.2% of tellurium were fed for 3, 5, 7, 9, 13 days to male wistar rats (21 days old) and then neurologic symptom and the feature of nerve fiber myelination were studied. From this study, following results were obtained. In 3 days treated group, it showed various neurologic symptom and teased nerve fiber showed slight irregularity of the myeline sheath. In 5 days and 7 days treated groups, it showed the segmental demyetination in larger size fiber and widening of nodes of ranvier. In 9 days and 13 days treated groups, the remyelinated fibers were observed and it was generally small in size. We consequently suggest that teasing nerve fiber method and quantitative analysis of nerve fiber were useful pathologic screening method of neurotoxicity of the peripheral nervous system.

키워드

Tellurium Segmental demyelination Teasing nerve fiber Quantitative analysis