디에탄올아민 디티오카바메이트의 백급(II)착물 합성 및 쥐의 cis-[$Pt(NH_{3})_{2}Cl_{2}$]에 의한 신장독성 회복

• 영문명: Synthesis of Platinum(II) Complex of Diethanolamine Dithiocarbamate and Rescue of cis-[$Pt(NH_{3})_{2}Cl_{2}$] Nephrotoxicity in Rats
• 발행기관: 한국환경보건학회
• 저자명: 우상철 김창수
• 간행물 정보: 『1. 한국환경보건학회지』제24권 제3호, 26~34쪽, 전체 9쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 1998.09.30

영문 초록

Diethanolamine Dithiocarbamate containing OH groups which gave water-soluble [Pt(dtc)$_{2}$] (diethanolamine dithiocarbamate) were synthesized from the reaction of CS$_{2}$ with diethanolamine. The complex has been characterized by elemental analysis, electrical conductivity, and spectroscopic results. Diethanolamine dithiocarbamate is effective as rescue and inhibition of cis-[$Pt(NH_{3})_{2}Cl_{2}$] nephrotoxicity in rats. It is suggested that diethanolamine dithiocarbamare removes platinum(II) complex coordinated to -SH groups of protein of kidney tubule cells.