Ketoconazole 처리에 의한 Candida albicans의 미세구조에 관한 전자현미경적 연구

• 영문명: THE ULTRASTRUCTURE OF CANDIDA ALBICANS AFTER IN VITRO EXPOSURE TO THE KETOCONAZOLE
• 발행기관: 대한구강악안면외과학회
• 저자명: 노수영(Soo Young Rho) 이의웅(Eui Wung Lee)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제12권 제2호, 135~143쪽, 전체 9쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 1986.12.30

영문 초록

Kotoconazole is a new systemic antifungal compound which is active by the oral route against superficial and systemic infections with Candida albicans. In this study, the author investigated the minimal inhibitory concentration of ketoconazole on C. albicans isolated from oral cavity and observed electron microscopically the ultrastructual changes of C. albicans which were acquired resistance against ketoconazole. The results were summarized as follows: 1. The minimal inhibitory concentrations of ketoconazole on C. albicans were 0.39㎍/㎖ in 20 strains (55.6%) and 0.19㎍/㎖ in 7 strains (19.4%), but even 50.0㎍/㎖ in 3 strains (8.3%) among 36 strains of Candida albicans. 2. The ultrastructual changes of acquired resistant C. albicans were observed as follows: (1) The shapes of cells showed horse-shoe shape, cone shape, rectangular shape and other abnormal shapes. (2) The cell wall became irregularly thickened and disruptured. (3) The dense veiscular structure accumulated in the cell wall. (4) The cell membrane was relaxed from the cell wall. (5) The cell membrane was disruptured and lyzed. (6) Many lipid droplets were increased in the cytoplasm. (7) Incomplete cell division was observed.

목차

I. 서론

II. 실험재료 및 방법

III. 실험성적

IV. 총괄 및 고찰

V. 결론

참고문헌

Abstract