골결손부의 신생골 형성에 미치는 흡수성, 비흡수성 및 우골유도 수산화인회석의 영향

• 영문명: Effect of resorbable, non-resorbable, and bovine-derived hydroxyapatite on the repair of experimental bone defects in dogs
• 발행기관: 대한구강악안면외과학회
• 저자명: 박문성(Mun Seong Park) 유선열(Sun Youl Ryu)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제22권 제4호, 561~574쪽, 전체 14쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 1996.10.30

영문 초록

The purpose of this study was to investigate the effects of resorbable, non-resorbable and bovine-derived hydroxyapatite(HA) on the repair of experimental bone defects. Six mongrel dogs, weighing 15kg, were used. Four surgical bone defects sized 1㎤ were created at the iliac bone under general anesthesia. In control group, the defect was filled with blood clot : in resorbable HA group, filled with resorbable HA: in non-resorbable HA group, filled with non-resorbable HA: and in bovine-derived HA group, filled with bovine-derived HA. The animals were sacrificed at 1, 2, 4, 8 and 12 weeks after the graft. Tissue specimens were obtained for radiographic and light microscopic examination. Results obtained were as follows: 1. Macroscopically, neither infection of the graft site nor dislodgement of the grafted material was noted. 2. In the examination of radiographic density, gray level of all of the HA groups was higher than that of the control group. The gray level increased in all groups with time, but the rate of increase was slowered in the non-resorbable HA group. 3. In the resorbable HA group. woven bone was formed from surrounding host bone through osteocondurction at 1 week after the graft. The bone defect was healed with bone trabeculae at 4 weeks and with mature bone at 8 weeks after the graft. 4. In the non-resorbable HA group, healing process was slower than that in the resorbable HA group and unresorbed HA particles were observed at 12 weeks after the graft. 5. In the bovine-derived HA group, bone trabeculae were formed through interconnection of woven bone matrix and the lamellar structure was seen in the 8 weeks after the graft. 6. In all HA groups, new bone formation was more rapid than that in the control group. There were no significant differences in the capability of bone formation among the three HA groups, where new bone was formed by osteoconduction. These results suggest that resorbable, non-resorbable, and bovine-derived hydroxyapatite can be used as bone substitutes to promote new bone formation in the bone defect.

목차

Abstract

I. 서론

II. 실험재료 및 방법

III. 결과

IV. 고찰

V. 결론

참고문헌

키워드

hydroxyapatite osteoconduction new bone formation