수종의 비골성 대체골이 섬유모세포에 미치는 세포독성에 관한 실험적 연구

• 영문명: An experimental study on the cytotoxic effect of various non-bone derived bone substitutes in fibroblast
• 발행기관: 대한구강악안면외과학회
• 저자명: 김태성(Tae Sung Kim) 이동근(Dong Keun Lee) 김수남(Soo Nam Kim)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제22권 제4호, 544~560쪽, 전체 17쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 1996.10.30

영문 초록

The morbidity associated with autologous bone graft substitutes. These include both bone derived and non-bone derived substitutes, each with advantages and disadvantages. Non-bone derived substitutes include gold, silver, tantalum, vitallium, stainless steel, aluminum, brass, magnesium, zirconium, lead, platinum, titanium, plaster of paris, silicone, teflon, methylmethacrylate, collagen matrix, calcium phosphate ceramic as hydroxyapatite and tri-calcium phosphate, bioactive glass, calcium sulfate. And hard tissue replacement as polymethylmethacrylate (PMMA) and polyhydroxyethyl methacrylate(PHEMA). The incroporation of a substitute is dependent on biological and biomechanical conditions at the graft site. Therefore we studied cytotoxic effect of Calcium carbonate(BIOCORALⓇ Inoteb, France), Calcium sulfate (CAPSETIM, Lifecore, USA), Hydroxyapatite (InterporeⓇ Interpore Co, USA) and Collagen (CollaCoteⓇ Calcitek Inc, USA) on rat 3T3 fibroblast in culture by neutral red(NR) assay, 5-diphenyl dimethyltetrazolium bromide(MTT) assay and sulforhodamine B(SRB) assay. Generally, calcium carbonate and calcium sulfate were represented less cytotoxity than hydroxyapatite and collagen matrix. We considered that the most cytotoxic material were collagen matrix of four experimental non-bone derived bone substitutes and that the more increasing amount of bone substitutes into the well, the more increasing cytotoxity.

목차

Abstract

I. 서론

II. 연구재료 및 방법

III. 연구 성적

IV. 총괄 및 고찰

V. 결론

참고문헌

키워드

non-bone derived bone cytotoxic effect Fibroblast