치과 임플란트에서 골개조 관련인자의 발현에 관한 연구

• 영문명: Expression of osteoclastogenesis related factors in dental implant patients
• 발행기관: 대한구강악안면외과학회
• 저자명: 류승희(Seong-Hee Ryu) 김방신(Bang-Sin Kim) 정승곤(Seunggon Jung) 한만승(Man-Seung Han) 국민석(Min-Suk Kook) 옥승호(Seung-Ho Ohk) 오희균(Hee-Kyun Oh) 박홍주(Hong-Ju Park)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제36권 제5호, 386~391쪽, 전체 6쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2010.10.30

영문 초록

Introduction: Bone resorption is a unique function of osteoclasts. Osteoclasts are a specialized macrophage polykaryon whose differentiation is regulated principally by macrophage colony-stimulating factors, receptor activator of nuclear factor κB ligand (RANK) ligand, osteoprotegerin (OPG), and interleukins (IL). Reflecting the integrin-mediated signals, osteoclasts develop a specialized cytoskeleton that allows it to establish an isolated micro-environment between itself and the bone, wherein matrix degradation occurs by a process involving proton transport. The levels of IL-1, IL-6, OPG, and prostaglandin E2 (PGE2) expression were evaluated to study the correlations between dental implant teeth and the adjacent teeth. Materials and Methods: The exudate of the gingival crevice acquired from dental implants, adjacent teeth, opposite teeth and contralateral teeth of 24 patients. Results: 1. The levels of IL-1, IL-6, OPG and PGE2 expression in dental implant teeth were higher than those of the contralateral teeth. 2. IL-1 revealed a higher expression level in the adjacent teeth than in dental implant teeth. 3. The dental implant teeth and adjacent teeth did not show a remarkable difference in the level of IL-1 expression. 4. All the other cytokines were strongly expressed in the dental implant compared to the adjacent teeth. Conclusion: These results suggest that there might be close correlation between dental implant teeth and adjacent teeth in terms of the expressions of cytokines that affect the development and regulation of osteoclasts.

키워드

Dental implants Cytokines Osteoclasts