Chlorpromazine으로 유발된 파킨슨증과 다중클론성고면역글로불린혈증

• 영문명: Chlorpromazine-induced Parkinsonism and Polyclonal Gammopathy
• 발행기관: 대한임상노인의학회
• 저자명: 김용방(Yong Bang Kim) 이시훈(Si Hoon Lee) 김중석(Joong Seok Kim)
• 간행물 정보: 『대한임상노인의학회지』대한임상노인의학회지 제17권 제1호, 39~41쪽, 전체 3쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2016.06.30

영문 초록

We report a 61-year-old woman who developed motor and non-motor symptoms of Parkinsonism and polyclonal gammopathy in response to long-term treatment of chlorpromazine. The temporal relationship between chlorpromazine discontinuation and the disappearance of motor symptoms of Parkinsonism and polyclonal gammopathy suggests a causal link. The action mechanism of chlorpromazine is related to its ability as a dopamine antagonist as well as anti-serotonergic, anti-cholinergic, anti-adrenergic and antihistaminergic properties, and the exposure of this drug can be associated with various side effects such as Parkinsonism, constipation and orthostatic hypotension. Chlorpromazine can also induce abnormalities in immune system. This report alerts neurologists and geriatricians that care for patients with Parkinsonism and depression.

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키워드

Chlorpromazine Drug-induced Parkinsonism Polyclonal gammopathy