노인에서 에스오메프라졸과 폐렴 간의 관계

• 영문명: The Association between Esomeprazole and Pneumonia in the Elderly
• 발행기관: 대한임상노인의학회
• 저자명: 김용광(Young Kwang Kim) 김용환(Yong Hwan Kim) 신현규(Hyun Gyu Shin) 이덕철(Duk Chul Lee)
• 간행물 정보: 『대한임상노인의학회지』대한임상노인의학회지 제17권 제1호, 22~28쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2016.06.30

영문 초록

Background: Proton pump inhibitors (PPIs) are widely and routinely used to treat gastric acid-related disorders, such as gastroesophageal reflux disease (GERD) and peptic ulcer disease, in both inpatient and outpatient settings. Moreover, due to the characteristics of the elderly, GERD is one of common geriatric diseases, and then PPIs could be prescribed more frequently and longer in the elderly. Thus, in this study, the association between esomeprazole use and the prevalence of pneumonia has been evaluated in the elderly. Methods: From the National Health Insurance Service-National Sample Cohort database of Korea from 2007 to 2010, the elderly were selected and separated into subgroups according to the gender (female vs. male) and GERD (GERD vs. non-GERD). Also, esomeprazole was divided into two groups according to the daily dose; ＜40 mg and ≥40 mg. Then, the subjects were subdivided according to the duration of esomeprazole treatment; 1 week, 2 weeks, 3 weeks, 30 days and ≥31 days. Logistic regression was also performed to identify the association between duration of esomeprazole administration and pneumonia. Results: The total of 4,091 elderly subjects were selected. However, the association between the use of esomeprazole and the prevalence of pneumonia had been failed to show a significant association (in ＜40 mg esomeprazole group P=0.698, 0.504, 0.961 and 0.682 respectively; in ≥40 mg esomeprazole group, P=0.348, 0.846, 0.01and 0.713 respectively) Conclusion: The esomeprazole use was not associated with the prevalence of pneumonia in the elderly.

목차

Abstract

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

REFERENCES

키워드

Proton pump inhibitor Pneumonia Esomeprazole Gastroesophageal reflux disease The elderly