우울증이 치매조기검진에서 간이정신상태검사의 선별검사 예측 정확도에 미치는 영향

• 영문명: Influence of Depression on the Prediction Accuracy of Mini-Mental State Examination as Screening Test for Early Detection of Dementia
• 발행기관: 대한노인정신의학회
• 저자명: 김세범(Se Beom Kim) 이정재(Jung Jae Lee) 이석범(Seok Bum Lee) 이경규(Kyung Kyu Lee) 백기청(Ki Chung Paik)
• 간행물 정보: 『노인정신의학』노인정신의학 제20권 제2호, 108~113쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2016.10.30

영문 초록

Objective：Depression and cognitive impairment are closely associated in old age. In this study, we investigate the influence of depression on the prediction accuracy of Mini-Mental State Examination (MMSE) as screening test for early detection of dementia. Methods：Three hundred and twenty one dementia patients and five hundred and thirty five normal control subjects were enrolled in this study. We administered both the Mini International Neuropsychiatric Inventory and the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet clinical and neuropsychological battery. We diagnosed depressive disorders according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition diagnostic criteria, and evaluated the severity of depressive symptoms using the revised Korean version of the Geriatric Depression Scale. Subjects were divided into two groups : 1) depressed group, 2) non-depressed group. We compared sensitivity, specificity, positive predictive value, negative predictive value, receiver operating characteristic curve, and areas of under the curve (AUC) of MMSE between two groups. Results：AUC of total group was 0.803 [95% confidence interval (CI)=0.774-0.833]. AUC of non-depressed group was the higher (0.855 ; 95% CI=0.823-0.887) than that of depressed group (0.767 ; 95% CI=0.710-0.824, p＜0.009). Conclusion：In non-depressed group, diagnostic accuracy and positive predictive value were higher than those of depressed group. Depression should be considered for effective and efficient national dementia screening and registry program.

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서 론

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고 찰

키워드

Depression Screening Dementia Mini-Mental State Examination Positive predictive value