MITF 발현 조절을 통한 개똥쑥 추출물 및 아테미시닌의 미백 개선 효과

• 영문명: The Skin Whitening Effect of Artemisia annua L. Extracts and Artemisinin through Modulation of MITF Expression
• 발행기관: 한국인체미용예술학회
• 저자명: 김미경(Mee-Kyung Kim) 김봉우(Bong-Woo Kim)
• 간행물 정보: 『한국인체미용예술학회지』한국인체미용예술학회지 제16권 제4호, 59~71쪽, 전체 13쪽
• 주제분류: 예술체육 > 예술일반
• 파일형태: PDF
• 발행일자: 2015.12.20

영문 초록

Artemisinin is known as a constituent of the medicinal plant, Artemisia annua L. and has been used in folk medicine to treat various ailments for centuries. In studies to investigate the whitening effect of Artemisia annua L. extracts and artemisinin as an active ingredient for whitening cosmetics, the effects of Artemisia annua L. extracts and artemisinin on melanogenesis in B16-F10 melanoma cells were identified. In a cell viability assay, Artemisia annua L. extracts and artemisinin did not show any obvious cytotoxicity, and they also significantly reduced both tyrosinase activity and the cellular melanin content in a concentration-dependent manner. Furthermore, it was found that artemisinin decreased α-MSH (melanocyte-stimulating hormone)-induced tyrosinase activity and microphthalmia associated transcription factor (MITF) protein expression. These dataindicate that Artemisia annua L. extracts and artemisinin attenuates α MSH-stimulated melanin synthesis by modulating MITF expression and that they might be a useful therapeutic agent for treating hyperpigmentation and an ingredient of whitening cosmetics.

목차

Ⅰ. 서 론

Ⅱ. 연구방법

Ⅲ. 연구결과 및 고찰

Ⅳ. 결 론

키워드

Artemisia annua L.(개똥쑥) pigmentation(색소침착) melanocyte(멜라닌생성세포) tyrosinase(티로시나아제) microphthalmia-associated transcription factor(MITF전사인자)