뇌혈관질환이 없는 노년기 우울증 환자에서 피질 두께의 감소

• 영문명: Reduced Cortical Thickness in Patients with Late Life Depression without Cerebral Vascular Disease
• 발행기관: 대한노인정신의학회
• 저자명: 이강윤(Kang Yoon Lee) 이영민(Young Min Lee) 박제민(Je Min Park) 이병대(Byung Dae Lee) 문은수(Eun Soo Moon) 정희정(Hee Jeong Jeong) 정영인(Young-In Chung) 김지훈(Ji-Hoon Kim)
• 간행물 정보: 『노인정신의학』노인정신의학 제19권 제2호, 1~4쪽, 전체 4쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2015.10.30

영문 초록

Objective：The aim of this study is to compare cortical thickness in late life major depression patients without cerebral vascular disease (CVD) with that of non-depressed normal comparison subjects using magnetic resonance imaging (MRI). Methods：Altogether, 47 subjects were finally recruited from the Memory impairment clinics of Pusan National University Hospital in Korea. All subjects (late life major depression patients without CVD : n=21, matched non-depressed normal compari-son subjects : n=26) underwent 3-tesla MRI. Results：Late life major depression patients without CVD showed reduced cortical thickness in left precuneus, left inferior temporal gyrus, and left cuneus compared with non-depressed normal comparison subjects. Conclusion：Our findings suggest that late life major depression without CVD is associated with reduced cortical thickness.

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대상 및 방법

결 과

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결 론

키워드

Late life major depression Cortical thickness Magnetic resonance imaging 노년기 우울증 피질 두께 뇌자기공명영상검사.