경도인지장애에서 추체외로 증상과 영역별 인지기능 저하 :A Clinical Research Center for Dementia of South Korea (CREDOS) Study

• 영문명: Extrapyramidal Signs and Impairment of Cognitive Subdomains in Mild Cognitive Impairment : A Clinical Research Center for Dementia of South Korea (CREDOS) Study
• 발행기관: 대한노인정신의학회
• 저자명: 박진홍(Jin Hong Park) 명우재(Woojae Myung) 최준배(Junbae Choi) 김상하(Sangha Kim) 강효신(Hyo Shin Kang) 나덕렬(Duk L. Na) 김성윤(Seong Yoon Kim) 이재홍(Jae-Hong Lee) 한설희(Seol-Heui Han) 최성혜(Seong Hye Choi) 김상윤(SangYun Kim) 김도관(Doh Kwan Kim)
• 간행물 정보: 『노인정신의학』노인정신의학 제19권 제2호, 1~7쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2015.10.30

영문 초록

Objective：This study investigated the association between extrapyramidal signs (EPS) and five cognitive sub-domains in a large number of patients with mild cognitive impairment (MCI). Methods：Our analyses considered 1,943 patients with MCI drawn from the nationwide Clinical Research of Dementia of South Korea study. EPS were defined as presence in patients with at least 1 of 11 operationally specified features. We assessed five cognitive sub-domains : attention, language, visuospatial function, memory, and frontal/executive function using the Seoul Neuro-psychological Screening Battery-Dementia version. The associations of EPS with each cognitive sub-domain were analyzed with a multiple linear regression model after controlling for confounding factors : sex, age, education years, diabetes, hypertension, sever-ity of global function, depressive symptoms, and white matter hyperintensities (WMH). Results：138 MCI patients (7.1%) had EPS. This group had more global cognitive deterioration and severe WMH. MCI pa-tients with EPS showed lower performance compared to those without EPS in 3 cognitive sub-domains: attention (p=0.05), vi-suospatial function (p=0.02), and frontal/executive function (p<0.0001). The language sub-domain and the memory sub-domain did not differ between the EPS positive and the EPS negative groups. Conclusion：EPS in MCI are associated with greater cognitive impairment in specific functional sub-domains rather than with global greater cognitive deterioration.

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키워드

Mild cognitive impairment Extrapyramidal signs Cognition 도인지장애 추체외로 증상 인지기능.