효과적인 진단 및 치료를 위한 스마트 나노 벡터에 관하여

• 영문명: About Smart Nanovector for the Effective Theranostics
• 발행기관: 한국방사선학회
• 저자명: 이훈재(Hwunjae Lee) 최규락(Guyrack Choi)
• 간행물 정보: 『한국방사선학회 학술대회 논문집』2014년 추계종합학술대회논문집, 67~68쪽, 전체 2쪽
• 주제분류: 공학 > 기타공학
• 파일형태: PDF
• 발행일자: 2014.11.22

영문 초록

The development of synchronized delivery and imaging system for small interfering RNA (siRNA) is required for the clinical application of RNA interference (RNAi) in cancer treatment. Herein, we report a pH-responsive, magnetic nanoparticle-based siRNA delivery system that can facilitate thesafe and efficient delivery and visualization of therapeutic siRNA by high-resolution magnetic resonance (MR) imaging. The synthesized nanovectors were then complexed with siRNA targeting the CD44 gene via electrostatic interaction to verify the specific gene-silencing effect. The imidazolized magnetic nanovector (ImMNV) architectures developed here facilitated improved cellular internalization and exhibited a high level in vitro downregulation compared to non-imidazolized MNVs in metastatic breast cancer cells.