Acacetin의 HeLa 세포 Apoptosis 유도 효과

• 영문명: Effect of Acacetin on the Apoptosis Induction of HeLa Cells
• 발행기관: 대한약학회
• 저자명: 한수정(Su Jung Han) 김안근(An Keun Kim)
• 간행물 정보: 『약학회지』제59권 제1호 (2015년), 17~22쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2015.02.27

영문 초록

In this study, we examined the effect of acacetin on the apoptosis induction of HeLa human cervical cancer cells. The results showed that acacetin inhibited the cell viability and induced apoptosis, leading to PARP cleavage and activation of caspase-9, -3, and -7. Moreover, acacetin-induced apoptosis was attenuated by a broad caspase inhibitor, z-VADfmk. Also, acacetin resulted in a loss of mitochondria membrane potential. Taken together, our results demonstrate that the induction of apoptosis by acacetin in HeLa cells is associated with caspase activation via the mitochondria pathway.

키워드

HeLa cells acacetin apoptosis