흰쥐에 경구 및 정맥투여시 에피가로카테친이 니모디핀의 생체이용률에 미치는 영향

• 영문명: Effects of Epigallocatechin Gallate on the Bioavailability of Nimodipine after Oral and Intravenous Administration in Rats
• 발행기관: 대한약학회
• 저자명: 이종기(Chong-Ki Lee) 최준식(Jun-Shik Choi) 최동현(Dong-Hyun Choi)
• 간행물 정보: 『약학회지』제55권 제4호 (2011년), 1~23쪽, 전체 23쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.08.30

영문 초록

The purpose of this study was to investigate the effect of epigallocatechin gallate (EGCG) on the pharmacokinetics of nimodipine in rats. Pharmacokinetic parameters of nimodipine were determined in rats after oral and iv administration of nimodipine with or without EGCG and also the effect of EGCG on the cytochrome P450 (CYP) 3A4 and P-glycoprotein (P-gp) activity were evaluated. EGCG inhibited CYP3A4 and P-gp activity. EGCG significantly increased the area under the plasma concentration-time curve (AUC) and peak plasma concentration (Cmax) of nimodipine. The absolute bioavailability (AB%) and relative bioavailability (RB%) of nimodipine by EGCG were increased by 16% and by 48%, respectively, compared to the control. In contrast, EGCG did not affect the intravenous pharmacokinetics of nimodipine. Based on these results, the increased bioavailability of nimodipine might be due to inhibition of CYP3A4 in the small intestine and/or in the liver and inhibition of P-gp in the small intestine by EGCG.

키워드

nimodipine epigallocatechin gallate bioavailability pharmacokinetics CYP3A4 P-gp rats