비소세포성폐암에 대한 자연살해세포의 항암효능

• 영문명: Anticancer Effect of Activated Natural Killer Cells on Human Non-small Cell Lung Cancer
• 발행기관: 대한약학회
• 저자명: 박민경(Min Gyeong Park) 성혜란(Hyeran Sung) 박지성(Ji-sung Park) 김지연(Jee Youn Kim) 한상배(Sang-Bae Han) 이종길(Chong-Kil Lee) 윤병규(Byung Kui Yun) 송석길(Sukgil Song)
• 간행물 정보: 『약학회지』제55권 제3호 (2011년), 267~272쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.06.30

영문 초록

Human NK cells, identified 30 years ago based on their ability to spontaneously kill tumor cells, constitute a subset of lymphocytes, which play an important role in the first line of immune defense and the effective function of these cells are enhanced by cytokines. Lung carcinoma has been one of the most commonly diagonosed cancer as well as the leading cause of cancer death in male. Here we provide the evidence that human natural killer cells has inhibitory effects on tumor growth of human lung cancer cell NCI-H460 (non-small cell lung cancer). Enriched NK cell population was obtained by 2 weeks cultivation in interleukin-2(IL-2)-containing medium. The resulting population comprised 26% CD3+ cells, 9% CD3+CD4+ cells, 16% CD3+CD8+ cells, 76% CD56+ cells, 6% CD3+CD56+ cells and 70% CD3-CD56+ cells. Activated NK cells at doese of 2.5, 5, and 10 million cells per mouse inhibited 2%, 12% and 45% of NCI-H460-induced tumor growth in nude mouse xenograft assays, repectively. This result suggests that NK cell-based immunotherapy may be used as an adoptive immunotherapy for lung cancer patients.

키워드

natural killer cells immunotherapy NCI-H460 lung cancer