승마 에탄올 추출물의 진정 효과

• 영문명: The Sedative Effects of Ethanol Extract from Cimicifugae Rhizoma
• 발행기관: 대한약학회
• 저자명: 최윤정(Yun Jung Choi) 윤서영(Seo Young Yoon) 최지영(Ji Young Choi) 우태선(Tae Seon Woo) 손건호(Kun Ho Son) 이용수(Yong Soo Lee) 정재훈(Jae Hoon Cheong)
• 간행물 정보: 『약학회지』제55권 제3호 (2011년), 213~218쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.06.30

영문 초록

The aim of this study is to evaluate the sedative effects of ethanol extract and the three major constituents of Cimicifugae Rhizoma. They decreased locomotor activity significantly, and enhanced sleeping duration induced by thiopental sodium. The ethanol extract of Cimicifugae rhizoma and 24-epi-7,8-didehydrocimigenol-3-xyloside (24-epi.) increased the Cl- influx into the intracellular area of SH-SY5Y neuroblastoma cells significantly. The present results demonstrate that the sedative effects of Cimicifugae rhizoma are mediated via the GABA-gated Cl- channel, partly by 24-epi.

키워드

Cimicifugae Rhizoma sedative effect Cl- influx GABA receptor triterpenoids