학술논문
Drug Design for Genome Targeting
이용수 0
- 영문명
- 발행기관
- 대한약학회
- 저자명
- Shigeki Sasaki
- 간행물 정보
- 『추계총회 및 학술대회』(2004년) vol.2, 128~131쪽, 전체 3쪽
- 주제분류
- 의약학 > 내과학
- 파일형태
- 발행일자
- 2004.10.30
4,000원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
목차
1. Functional molecules for specific covalent bond form ation with inducible reactivity
2. Cytidine-specific nitrosyl (NO) transfer reaction leading to deam ination
3. Non-natural nucleoside analogs for the formation o f triplex DNA
4. Delivery system s for the use of the functional oligonucleotides in the living cells
키워드
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- Anti-diabetic potential of ginsenosides, the major active components of ginseng by an analysis of the effect on insulin receptor signaling
- Method Development for Simultaneous Profiling Analysis of Amines and Phenols as Ethoxycarbonylated Pentafluoropropionyl Derivatives by Gas Chromatography and its Clinical Applications
- Antiflbrotic Effects of Transforming Growth Factor Β type I Receptor Kinase (ALK5) Inhibitor on Liver Fibrosis in Rats with Bile Duct Ligation
- Cationic solid lipid nanoparticles for in vivo gene delivery based on the dermal application
- Pharmacodynamics of 5-FU in three-dimensional culture of human tumor cells
- Effects of Protaetia Orientalis (Gory et Perchlon) Larva on lipid and ethanol metabolism in the ethanol-intoxicated model
- Stress related activities of Gardenia Jasminoides in SD Rats and ICR Mice
- Inhibition of IκB release through IKKs modification by melittin resulted in reduced generation of inflammatory mediators
- Cytotoxic Constituents of a Marine Sponge Homaxinella sp
- In vitro anti-inflammatory effect of buddleja saponin Ⅳ isolated from Pleurospermum kamtschatidum in LPS-induced RAW 264.7 murine macrophage cells
- Microarray analysis of gene expression profile induced by Acetaminophen on mice hepatocytes
- Effects of herbal extracts on the level of lipid and hepatotoxicity of rats with alcohol induced liver injury
- Interaction of HDAC4 with LMO4 play an important role in gene transcription
- Roles of glycolytic processes on the IgE receptor - mediated allergic and inflammatory responses
- Anti-inflammatory effects of Thioctic acid in Iipopolysaccharide(LPS)-induced BV-2 murine microglia
- Corbrotoxin interacts with proteins of NF-κB signal pathway resulted in inhibition of NF-κB target gene expression
- The Reduction of Melanin Synthesis by Transforming Growth Factor-β1
- DW1350, a Newly Synthetic Anti-osteoporotic Agent : 5. Effect of DW-1350 in Rib Fracture Rat Model, a Histomorphometrical Aspect
- Gene Expression Patterns as Potential Molecular Biomarkers For Cadmium Exposure
- Activation of Transcriptional Factors Precedes Cyclooxygenase-2 Gene Expression in Macrophages Exposed to the Chicken Ovalbumin
- DDT reduced testosterone via induction of aromatase genes expression in rat testicular Leydig cells
- Characterization of a 68 kDa Cytosolic Mg²+ -independent Neutral Sphingomyelinase
- DW1350, a Newly Synthetic Anti-osteoporotic A gent : 6. Action Mechanism of DW-1350
- Phthalates Inhibit Tamoxifen-induced Apoptosis in MCF-7 Human Breast Cancer Cells
- Role of metabolism in 1,2:5,6-dibenzanthracene-induced immunosuppression in female BALB/c mice
- Enantiomeric seperation methamphetamine trafficed in Korea
- Down-regulation of murine CYP1A1 in hepa-1c1c7 cells by 3',4',3,5,7-O-methylated epicatechin
- Ceramide induces the generation of reactive oxygen species in activated RAW 264.7 murine macrophage cells
- Natural Products Screening for Inhibitors Selectively Inhibiting a 60 kDa Membrane-associated, Mg²+ -dependent Neutral Sphingomyelinase Activity
- Role of Nitric Oxide in the Expression of Hepatic Vascular Stress Genes in Response to Sepsis
- Anti-inflammatory effect of tormentic acid fractioned from Rubus coreanus on lipopolysaccharide induced RAW 264.7 cell
- Ameliorating effect of herbal extracts on postmenopausal disorders in ovariectomized rats
- Inhibitory effects of caffeic acid phenethyl ester on angiogenesis
- Preclinical Drug-Drug Interaction Study of DW-224a, a Novel Fluoronaphyridone
- Studies on cytokine expression and agglutination of cancer cells with lectins from Allomyrina dichotoma and Bombyx mori
- Hydrogen peroxide mediates Rac1 activation of S6K1
- Metallothionein-Ⅲ treatment decreases secretion of amyloid beta-protein in neuroblastoma cells
- Evaluation of dietary plant flavonoids against BKF-induced CYP1B1 gene expression in MCF-7 human breast carcinoma cells
- Hepatoprotective activity of ginsenoside Rh2 on tert-butyl hydroperoxide-induced liver injury
- Effects of cadmium on estrogen receptor and cell death induction in human breast cancer cells
- The Effect of Histone Deactylase inhibitors on the Ceil Proliferation and Apoptosis in Human Breast Cancer Cell Lines
- Regulations of human CYP3A4-XREM promoter activities in Hepa I and HepG2 cells
- In vitro Preclinical Studies of AdLPCD, AdLPE1A and AdLPCDIRESE1A Recombinant Adenoviral Vectors for Hepatocellular Carcinoma
- Ameliorating Effect of herbal extracts on menopausal urinary incontinence in ovariectomized rat
- Chemopreventive Effect Of Gingko Biloba Extract(GBE) In Human Breast Cancer Cell
- Quercitirn gallate inhibits LPS-inducde NF-kB activation and exhibits antioxidant effect
- A study of Aceclofenac employing microemulsion systems for percutaneous delivery
- Obovatol, A Major Component of Leaves of Magnolia Obovata, Inhibits Rat Aortic Vascular Smooth Muscle Cell Growth by Induction of p21Waf/Cip1
- Shear stress induced pH increase in plasma is mediated by Pco2 decrease and pH increase alone can enhance shear stress induced P-selectin expression in platelets
- Anti-cancer effect of STB-HO (mineral complex containing rare earth elements) in nude mice transplanted human breast cancer cells
- The effect of manufacturing conditions on the drug distribution and its release profile from human growth hormone loaded PLGA microsphere formulation
- Induction of apoptosis by a stilbene analog in cancer cells
- Boron contents in C57BL mouse tissues by administration of boron compounds and preliminary effect of BNCT
- Development of Anticancer Agents Derived from Natural Phenanthroindolizidine Alkaloids
- Chemopreventive agent Resveratrol; mechanisms of cancer prevention on the human breast cancer cell lines
- Tumor targeting by covalent conjugation of a ω -6 natural fatty acid to paclitaxel
- Protection of Paecilomyces tenuipes against carbon tetrachloride-induced hepatotoxicity in vitro and in vivo
- Modulation of Cytochrome P450 Enzymes by Diesel Exhaust Particles in Primary Cultures of Adult Rat Hepatocytes
- Fractionation of acharan sulfate by ceruloplasmin affinity column
- Effect of Adapted Low Temperature and Medium Composition on Growth and Erythropoietin (EPO) Production by Chinese Hamster Ovary Cells
- Potency of inducers of dioxin receptor-regulated CYP1A1 activity in human hepatoma cell line, HepG2
- Homology Modeling and Virtual Screening with Voltage Dependent T-type Ca²+ Channel
- TNF-α and 7-ketocholesteroI cooperate to induce death in human vascular smooth muscle cell
- Characteristics of the Resistance to Macrolide-Lincosamide-Streptogramin B Antibiotics in Staphylococcus aureus Isolates from the Hospitalized Patients and Healthy Subjects
- Structural Aspect of Chalcones for the Inhibitory activity of IL-5
- Role of nitric oxide and p53 in chloroquine-induced apoptosis in A172 human glioma cells
- Functional conservation of polo kinases in both budding yeast and human
- Property-based design of CNS-targeted library
- TGF-β-activated p38 signaling is critical for up-regulation of MMP-2 and MMP-9 in breast epithelial cells
- Synthesis of Conformationally Locked Carbocyclic Nucleoside Ring System from (+)-(1R,4R)-4-(Benzyloxymethyl)-4-(hydroxymethyl)cycIopent-2-enol
- H-ras mediates type-I collagen-dependent activation of pro-MMP-2 through up-regulation of MT1-MMP in breast epithelial cells
- Synthesis of Asymmetric Dimer of Quinolone Derivatives; Aza Analogs of Flavanones
- The proliferation and differentiation of neural stem cell from mouse embryonic forebrain
- Anti-cancer activities of Favonoids in Hep3B and SK-Hep1
- Synthesis and Evaluation of 5,8-quinoxalinediones as Vascular Smooth Muscle Cell Proliferation Inhibitor
- Synthesis and In vivo evaluation of Selenoflavanone : A New class of Neuroprotective agent
- C-Reactive Protein Induces Apoptosis in Human Monocytic Leukemia Cells
- Development of in silico prediction model for hERG protein binding activity
- A New Method for Macrodiolide Formation Using Selenol Ester
- Synthesis and Antibacterial Activity of DW-224a, A New Fluoronaphthyridine Antibiotic
- In silico screening approach for hit identification of GSK-3β inhibitors
- Synthesis of new apicidin derivatives as potent histone deacetylase inhibitors (HDAC)
- Establishment of a Cisplatin-Resistant Gastric Carcinoma Cell Line YCC-3/R
- EK-6136, (3-M ethyl-4-(O-methyl-oximino)-1-phenylpyrazolin-5-one): A novel Cdc25B inhibitor with antiproliferative activity
- Discovery of Novel Ligands for RNA Pseudoknot of SARS Coronavirus by Virtual Screening and -1 Ribosomal Frameshifting Assay
- Synthesis of 1,8-naphthyridins as anticancer agents
- Development of Synthetic Methodology for Furofuran Lignans
- Inhibition of CDK2 activity by dehydrocostuslactone and costunolide
- Effect of Streptococcus pneumoniae adh mutation on gene expression in the A549 cells
- in silico Screening Approach for Hit Identification of PTP1B Inhibitors
- Structure-Activity Relationship Study of Gentisic Acid Esters as Potential Skin Whitening Agents
- Synthesis and antifungal activity of 5-arylamino-4,7-dioxobenzo[b]thiophenes
- Design and Synthesis of D-4'-Thioadenosine derivatives as ultrapotent and selective agonists at the human A₃adenosine receptor
- Safety assessment of potential lactic acid bacteria Bifidobacterium longum SPM1205 isolated from healthy Korean in SD rats
- Total synthesis of Apiddin A and side chain modified Derivatives as Potent Antitumor Agents
- Rac pathway is critical for capsaicin-induced apoptosis of H-ras-transformed human breast epithelial cells through ROS generation
- Asymmetric synthesis of novel thioiso dideoxynucleosides with exocyclic methylene as potential antiviral agents
- New antibiotics of the nocardamine class from a marine-derived Streptomyces sp.
- Superior antitumor efficacy of Genexol?-PM, a biodegradable polymeric micelle-based formulation of paclitaxel (Genexol?) compared with Gemcitabine and Taxol in human pancreatic cancer
- Cardioprotective effect of KR-32560, a novel sodium/hydrogen exchanger-1 inhibitor, on ischemia/reperfusion heart injury in rat
- Korea Red Ginseng Water Extract Increases Nitric Oxide Concentrations in Exhaled Breath
- Anti-Oxidative compounds of Polygonum multiflorum Aerial Parts
- Anticancer Effect and Gene Expression Regulation of Major Constituent of Green Tea, EGCG in Gynecologic Cancers
- Characterization of Recombinant Human Growth Hormone loaded Phosphazene Formulation as Injectable Drug Delivery System
- Contribution to the anti-inflammatory potential of sulfuretin isolated from the heartwood of Rhus verniciflua through down-regulation of IκB kinase and NF-κB activation in macrophages
- Simultaneous Chiral Discrimination of β-Blockers as Diastereomeric N-(-)-Menthoxycarbonylated O-Trimethylsilyl Derivatives by Achiral Gas Chromatography
- Reversal of multidrug resistance by benzotriazepin analogues in cancer cells (Ⅱ)
- Safety and Efficacy Assessment in Cell and Gene Therapy Products : Today's Thinking for Tomorrow's Success
- Toward a Therapeutic Application of Artificial Transcription Factors
- Monoamine Oxidase Inhibitory Components from the aerial parts of Dictatnnus albus
- Potent and Selective Inhibitors of CDK2 as antitumor Agents: Synthesis, SAR Analysis, and Biological Activity
- Diastereoselective Synthesis of Unsaturated 1,2-Amino Alcohols from α-Hydroxy Allyl Ethers Using Chlorosulfonyl Isocyanate
- Capacitative Calcium Entry Is Involved In Regulation of Muscarinic Stimulation of Nf-Kb Mediated Sappa Release
- Five oleanene-triterpene glycosides from the leaves of Acanthopanax sieboldianus
- Therapeutic concentration of antipsychotic drugs in patients of psychiatric disorders
- Risk Analysis of Drug Adverse Reaction: in Case of PPA
- Anticancer constituents with topoisomerase inhibitory activity from the roots of Rubia cordifolia L.(Ⅱ)
- The effects of dietary flavonoids on the benzo(k)fluoranthene-induced CYP1A1 gene expression
- Down-regulation of murine CYP1A1 in mouse hepatoma hepa-1c1c7 cells by biochanin A
- Inactivation of the Erk1/2 Pathway by Map Kinase Phosphatase-1 Mediates Hydrogen Peroxide-Induced Cell Death in Sh-Sy5y Cells
- A new conceptional double staining for protein in SDS-PAGE using azo dye as silver ion sensitizer
- Immune-Enhancing Effect of Mountain Grown Ginseng
- The docked models of COX-2 inhibitors
- The 3D-QSAR Study of Quinoline Derivatives with Antifungal Activity by CoMFA
- The protective effect of methanol extracts from Acanthopanax koreanum Nakai against skin aging
- NF-κB inhibitors from Artemisiae asiaticae Herba
- Quantitative Analysis of Commercial Herbal Medicines and study on identification method by LC/MS
- 1. Cytotoxic activity of 1,8-naphthyridins derivatives
- Sensitive Determination of Pinaverium Bromide in Human Plasma by LC-ESI-MS/MS : Applicability to Oral Bioavailability Determination
- Protective effects of Gingko biloba Water Extract on the ischemia induced 4-vessel occlusion and cognitive impairments in the rat
- Quality evaluation of Saussureae Radix by HPLC
- Discovery of P-glycoprotein Modulators from Natural Products
- Simple method for preparation of active S-(-)- bisoprolol
- KFDA Implementation Policy of KDMF
- Inhibitory effects of xanthorrhizol on LPS-induced nitric oxide (NO) production and human cancer cell proliferation
- Stereoselective Formal Total Synthesis of Trehazolin
- Increase in Intracellular Calcium mediates dopamine release through the production of ceramide via Sphingomyelin Pathway in PC 12 cells
- DW1350, a Newly Synthetic Anti-osteoporotic Agent : 4. Effect on Ovariectomized and Neurectomized Osteoporosis Mice Model, a Histomorphometrical Aspect
- Safety test of chitosan oligosaccharide in Mice : Micronucleus and chromosome aberration test
- Proteomic analysis of synaptic vesicle from rat brains
- p43, a cofactor of tRNA synthetase, enhances T helper type 1 response by inducing interleukin-12 production in macrophages via NF-κB activation
- New Bisindole Alkaloids from the Marine Sponge Spongosorites sp.
- Anti-gastritic effect and cytotoxicity of Amomum villosum
- Regulation of Fumonisin B1-induced toxicity by sphingolipid methabolism
- Determination of itraconazole in human plasma by high-performance liquid chromatography with UV detection
- Development of liquid chromatographic method for determining melilotus extract in pharmaceutical preparations
- Biomimetic Micro-Nano fibrous scaffold for chondrocyte culture
- Therapeutic Effects of the Preparation of Lithospermi Radix and Gardeniae Fructus Extracts on the Burn and Wound Healing
- Study on Polymorphism of DA-6034
- Rapid Screening of Drug Blood-Brain Barrier Permeation Potential Using the Immobilized Artificial Membrane Phosphatidylcholine Column and Molar Volume
- Inhibition of prostaglandin production by a structurally-optimized flavonoid derivative, 2',4',7-trimethoxyflavone and cellular action mechanism
- CAP: Evaluation of risk factors for hospitalization and comparison of empiric regimens for efficacy and toxicity
- 19α-Hydroxyursane-type Triterpenoids, Antinociceptive Anti-inflammatory Principles of the Roots of Rosa rugosa
- Constituents from the stems of Parthenocissus tricuspidata and their DNA topoisomerases I andⅡinhibition and cytotoxicity
- Process Analytical Technology (PAT) for Pharmaceutical Industries
- Anti-obesity effect of STB-BM (mineral complex containing rare earth elements) in rats fed high fat diets
- Silibinin, A Major Active Component of Silymarin, Inhibits Rabbit Platelet Aggregation
- 15-Deoxy-Δ¹²,¹⁴-Prostaglandin J₂Protects Against Nitrosative PC12 Cell Death through Up-reguiation of Intracellular Glutathione Synthesis
- TNFα -308 and TNFβ +252 locus plays an important role in the etiopathogenesis of cerebral infarction
- The Studies on the Quality Control and the Revision of Acanthopanacis Cortex Monograph in Korean Pharmacopoeia
- Euonymus alatus prevents the onset of high-fat diet induced hyperglycemia in ICR mice and improves insulin resistance in C57BL/6J ob/ob mice
- Anti-inflammatory mechanism of benzoxathiol LYR-64 compound in LPS-stimulated macrophages RAW264.7
- Distinguishment of two polymorphic forms (Q&R) of Paraoxonase1 by Linoleic acid
- Ca2+Signaling in Atrial Myocytes: Evidence from 2-D Rapid Confocal Imaging
- Safety Evaluation of Biotech-derived Pharmaceuticals such as Papillomavirus Recombinant Vaccine Candidate
- p-85 beta PIX is necessary for cell motility via focal adhesion kinase phosphorylation
- Characterization of a Novel Calcium-independent Phospholipase A₂in Bovine Brain
- N-4-Substituted-benzyl-N'-tert-butylbenzyl Thioureas as Vanilloid Receptor Ligands : Investigation on the Role of Methanesulfonamido group in Antagonistic Activity
- Identification of rat syncytiotrophoblast Ⅰ,Ⅱ specific genes using conditionally immortalized syncytiotrophoblast TR-TBTs cell lines
- Identification of +1 Ribosomal Frameshifting site of Leishmania RNA virus by mutation analysis
- Anti-psoriatic Activity of Chunghyuldan on Oxazolone-induced Contact Dermatitis in Mice
- Deproteinization of Plasma Sample by Solld-Phase Extraction in Gel Filtration Mode using Sephadex G-10 Column
- Preparation and characterization of solid lipid nanoparticles (SLNs) containing paclitaxel
- Characterization and carbohydrate binding specificity of lectin isolated from Maackia fauriei
- Bioequivalence of Bendipine™ Tablet to Codipine™ Tablet (Benidipine Hydrochloride 4 mg)
- Impact of CYP2C9 polymorphism on Flurbiprofen pharmacokinetics in healthy Korean population
- Haplotype analysis of the MDR1 (exon 12, 21 and 26) genes in Korean population and no effect of the MDR1 haplotypes on sparfloxacin disposition
- E7-Expressing HaCaT Keratinocytes Are Resistant to Oxidative Stress-Induced Cell Death via Induction of Catalase
- Human Papillomavirus Vaccines in Preclinical Development
- A Fatal Case related to DDS Intoxication
- New Lignans with Antioxidant Activity from the Stem Bark of Styrax japonica
- Pharmacognostical Studies on the Dang Gui from Korea
- Construction and expression of a single-chain Fv fragment against berberine in Escherichia coli
- Hair growth effect of Biota orientalis extract
- Determination of Tectochrysin in the Korean Propolis by HPLC
- Simultaneous determination of niflumic acid and its prodrug, talniflumate in human plasma by high performance liquid chromatography
- Rapid and Sensitive Determination of Oxiracetam in Human Plasma by LC/MS/MS
- Analysis of acanthoic acid and isomers in Acanthopanax species
- Pharmacokinetic study of cefprozil diastereomers in human plasma by high performance liquid chromatography
- Overexpressing porcine IL-18 genes in porcine kidney cell induces mouse anti-pig cellular rejection in cellular xentransplatation
- The oligosaccharide analysis of sialylated glycoproteins using a high-performance liquid chromatography
- Preparation and Characterization of Chitosan adsorbed Solid Lipid Nanoparticles containing 7-Dehydrocholesterol
- Dexamethasone ameliorates peritoneal ascites, but has no therapeutic advantages in liver fibrosis
- Prediction of human pharmacokinetics of apicidin by using physiologically-based pharmacokinetic model
- Design and synthesis of non-peptide bradykinin antagonists and evaluation of their inhibitory activity on guinea-pig ileum contraction
- New meroditerpenoids from a marine brown alga Sargassum sp.
- Antioxidant Activity of Pine (Pinus densiflora Sieb. et Zucc) : Scavenging Activity against Superoxide Radical and 1,1-diphenyl-2-picrylhydrazyl(DPPH) Free Radical
- Activation of MKK6 Induces Invasive and Migrative phenotypes in MCF10A Human Breast Epithelial cells
- Development of method for improving extraction efficiency of D-amygdalin in Ma-whang tang as traditional oriental preparation
- NMR spectroscopy and pattern recognition methods for metabolic urinalysis of experimental animals
- The Studies on the Establishment of Correct Identity and Features of Acanthopanacis Cortex
- Total synthesis of (-)-Anisomycin
- Astrocyte activation-dependent neuronal cell differentiation by erythropoietin
- Metabolism of an anti-inflammatory propenone compound in rat liver microsomes
- Novel g-Lactam base Histone Deacetylase (HDAC) Inhibitors : Synthesis and Biological Evaluation
- Drug Design for Genome Targeting
- Regulation of Immunomodulating Gene Expression in RAW264.7 Murine Macrophage by Taurine
- Inhibitory Effect of Saenghyulyeunbueum-Ghami on Mast Cell-Mediated Allergic Inflammatory Reactions
- The investigation of biologically active compound from Protaetia brevitarsis larva
- Growth Inhibitory and Apoptotic Effect of Linarin Acetate on Human Prostate Carcinoma Cells
- Enantioseparation of levodopa for quality evaluation
- Quality evaluation of Acanthopanax species by CE
- HPLC determination and phalmamkinetic profile of Talniflumate in Korean volunteers
- Pharmacokinetics of Heptaplatin combined with 5-FU : Phase Ⅰ/Ⅱ Clinical Trial against Head and Neck Cancer
- Emulsion lyophilization technique suitable for improved loading of hydrophilic drugs into solid lipid nanoparticles
- Apoptosis induced by novel quinoline compound, KYS-50248 in HL-60 human promyelocytic leukemia cells through death receptor and mitochondrial pathway
- Three new alkaloids from Aconitum pseudolaeve var. erectum
- Protective agents against sepsis from the root of Saururus chinensis
- Phytochemical Constituents of Rhododendron brachycarpum
- Anti-stress Effect of extract mixed with Schizandra chinensis and Scutellaria baicalensis
- Cytotoxic Chalcones from Chinese Licorice
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