학술논문
Risk Analysis of Drug Adverse Reaction: in Case of PPA
이용수 2
- 영문명
- 발행기관
- 대한약학회
- 저자명
- Sun Hee Lee
- 간행물 정보
- 『추계총회 및 학술대회』(2004년) vol.2, 118~120쪽, 전체 2쪽
- 주제분류
- 의약학 > 내과학
- 파일형태
- 발행일자
- 2004.10.30
4,000원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
The risk managements for marketing products are generally based on the risk assessment of adverse reactions. Sometimes, marketing medicines shows unwanted adverse reaction, because in pre-marketing safety data with limitations of patients numbers the adverse reaction with low prevalence rate can not be easily detected. The association between unwanted adverse reaction and marketing medicine can be studied by following types; case report, case series study, case-control study, cohort study. In August, 2004, the KFDA banned the production and sale of cold remedies containing phenylpropanolamine(PPA), while US FDA requested drug companies discontinuing marketing products -containing PPA, in November, 2000. Both of regulatory decisions in USA and Korea were based on the case-control studies about an association between hemorrhagic stroke and PPA-containing appetite suppressants and cold remedies, respectively. The regulatory history of PPA in USA and the comparative analysis of the case-control studies in USA and Korea on an association between hemorrhagic stroke and PPA are presented in this symposium.
목차
키워드
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- Induction of G1 cell cycle arrest and apoptosis by a novel A3 adenosine receptor agonist LJ-529 in human leukemia cells
- Antiplatelet Activity and Mechanism of KR-32560, A Selective Sodium-Hydrogen Exchanger Isoform 1 (NHE-1) Inhibitor, on Rabbit Platelet
- Effects of KP586-A on neurite outgrowth in PC12 cells
- Protaetia Orientalis (Gory et Perchlon) Larva improves insulin actions and increases glycogen content
- Anti-diabetic potential of ginsenosides, the major active components of ginseng by an analysis of the effect on insulin receptor signaling
- Method Development for Simultaneous Profiling Analysis of Amines and Phenols as Ethoxycarbonylated Pentafluoropropionyl Derivatives by Gas Chromatography and its Clinical Applications
- Antiflbrotic Effects of Transforming Growth Factor Β type I Receptor Kinase (ALK5) Inhibitor on Liver Fibrosis in Rats with Bile Duct Ligation
- Cationic solid lipid nanoparticles for in vivo gene delivery based on the dermal application
- Pharmacodynamics of 5-FU in three-dimensional culture of human tumor cells
- Effects of Protaetia Orientalis (Gory et Perchlon) Larva on lipid and ethanol metabolism in the ethanol-intoxicated model
- Stress related activities of Gardenia Jasminoides in SD Rats and ICR Mice
- Inhibition of IκB release through IKKs modification by melittin resulted in reduced generation of inflammatory mediators
- Cytotoxic Constituents of a Marine Sponge Homaxinella sp
- In vitro anti-inflammatory effect of buddleja saponin Ⅳ isolated from Pleurospermum kamtschatidum in LPS-induced RAW 264.7 murine macrophage cells
- Microarray analysis of gene expression profile induced by Acetaminophen on mice hepatocytes
- Effects of herbal extracts on the level of lipid and hepatotoxicity of rats with alcohol induced liver injury
- Interaction of HDAC4 with LMO4 play an important role in gene transcription
- Roles of glycolytic processes on the IgE receptor - mediated allergic and inflammatory responses
- Anti-inflammatory effects of Thioctic acid in Iipopolysaccharide(LPS)-induced BV-2 murine microglia
- Corbrotoxin interacts with proteins of NF-κB signal pathway resulted in inhibition of NF-κB target gene expression
- The Reduction of Melanin Synthesis by Transforming Growth Factor-β1
- DW1350, a Newly Synthetic Anti-osteoporotic Agent : 5. Effect of DW-1350 in Rib Fracture Rat Model, a Histomorphometrical Aspect
- Gene Expression Patterns as Potential Molecular Biomarkers For Cadmium Exposure
- Activation of Transcriptional Factors Precedes Cyclooxygenase-2 Gene Expression in Macrophages Exposed to the Chicken Ovalbumin
- DDT reduced testosterone via induction of aromatase genes expression in rat testicular Leydig cells
- Characterization of a 68 kDa Cytosolic Mg²+ -independent Neutral Sphingomyelinase
- DW1350, a Newly Synthetic Anti-osteoporotic A gent : 6. Action Mechanism of DW-1350
- Phthalates Inhibit Tamoxifen-induced Apoptosis in MCF-7 Human Breast Cancer Cells
- Role of metabolism in 1,2:5,6-dibenzanthracene-induced immunosuppression in female BALB/c mice
- Enantiomeric seperation methamphetamine trafficed in Korea
- Down-regulation of murine CYP1A1 in hepa-1c1c7 cells by 3',4',3,5,7-O-methylated epicatechin
- Ceramide induces the generation of reactive oxygen species in activated RAW 264.7 murine macrophage cells
- Natural Products Screening for Inhibitors Selectively Inhibiting a 60 kDa Membrane-associated, Mg²+ -dependent Neutral Sphingomyelinase Activity
- Role of Nitric Oxide in the Expression of Hepatic Vascular Stress Genes in Response to Sepsis
- Anti-inflammatory effect of tormentic acid fractioned from Rubus coreanus on lipopolysaccharide induced RAW 264.7 cell
- Ameliorating effect of herbal extracts on postmenopausal disorders in ovariectomized rats
- Inhibitory effects of caffeic acid phenethyl ester on angiogenesis
- Preclinical Drug-Drug Interaction Study of DW-224a, a Novel Fluoronaphyridone
- Studies on cytokine expression and agglutination of cancer cells with lectins from Allomyrina dichotoma and Bombyx mori
- Hydrogen peroxide mediates Rac1 activation of S6K1
- Metallothionein-Ⅲ treatment decreases secretion of amyloid beta-protein in neuroblastoma cells
- Evaluation of dietary plant flavonoids against BKF-induced CYP1B1 gene expression in MCF-7 human breast carcinoma cells
- Hepatoprotective activity of ginsenoside Rh2 on tert-butyl hydroperoxide-induced liver injury
- Effects of cadmium on estrogen receptor and cell death induction in human breast cancer cells
- The Effect of Histone Deactylase inhibitors on the Ceil Proliferation and Apoptosis in Human Breast Cancer Cell Lines
- Regulations of human CYP3A4-XREM promoter activities in Hepa I and HepG2 cells
- In vitro Preclinical Studies of AdLPCD, AdLPE1A and AdLPCDIRESE1A Recombinant Adenoviral Vectors for Hepatocellular Carcinoma
- Ameliorating Effect of herbal extracts on menopausal urinary incontinence in ovariectomized rat
- Chemopreventive Effect Of Gingko Biloba Extract(GBE) In Human Breast Cancer Cell
- Quercitirn gallate inhibits LPS-inducde NF-kB activation and exhibits antioxidant effect
- A study of Aceclofenac employing microemulsion systems for percutaneous delivery
- Obovatol, A Major Component of Leaves of Magnolia Obovata, Inhibits Rat Aortic Vascular Smooth Muscle Cell Growth by Induction of p21Waf/Cip1
- Shear stress induced pH increase in plasma is mediated by Pco2 decrease and pH increase alone can enhance shear stress induced P-selectin expression in platelets
- Anti-cancer effect of STB-HO (mineral complex containing rare earth elements) in nude mice transplanted human breast cancer cells
- The effect of manufacturing conditions on the drug distribution and its release profile from human growth hormone loaded PLGA microsphere formulation
- Induction of apoptosis by a stilbene analog in cancer cells
- Boron contents in C57BL mouse tissues by administration of boron compounds and preliminary effect of BNCT
- Development of Anticancer Agents Derived from Natural Phenanthroindolizidine Alkaloids
- Chemopreventive agent Resveratrol; mechanisms of cancer prevention on the human breast cancer cell lines
- Tumor targeting by covalent conjugation of a ω -6 natural fatty acid to paclitaxel
- Protection of Paecilomyces tenuipes against carbon tetrachloride-induced hepatotoxicity in vitro and in vivo
- Modulation of Cytochrome P450 Enzymes by Diesel Exhaust Particles in Primary Cultures of Adult Rat Hepatocytes
- Fractionation of acharan sulfate by ceruloplasmin affinity column
- Effect of Adapted Low Temperature and Medium Composition on Growth and Erythropoietin (EPO) Production by Chinese Hamster Ovary Cells
- Potency of inducers of dioxin receptor-regulated CYP1A1 activity in human hepatoma cell line, HepG2
- Homology Modeling and Virtual Screening with Voltage Dependent T-type Ca²+ Channel
- TNF-α and 7-ketocholesteroI cooperate to induce death in human vascular smooth muscle cell
- Characteristics of the Resistance to Macrolide-Lincosamide-Streptogramin B Antibiotics in Staphylococcus aureus Isolates from the Hospitalized Patients and Healthy Subjects
- Structural Aspect of Chalcones for the Inhibitory activity of IL-5
- Role of nitric oxide and p53 in chloroquine-induced apoptosis in A172 human glioma cells
- Functional conservation of polo kinases in both budding yeast and human
- Property-based design of CNS-targeted library
- TGF-β-activated p38 signaling is critical for up-regulation of MMP-2 and MMP-9 in breast epithelial cells
- Synthesis of Conformationally Locked Carbocyclic Nucleoside Ring System from (+)-(1R,4R)-4-(Benzyloxymethyl)-4-(hydroxymethyl)cycIopent-2-enol
- H-ras mediates type-I collagen-dependent activation of pro-MMP-2 through up-regulation of MT1-MMP in breast epithelial cells
- Synthesis of Asymmetric Dimer of Quinolone Derivatives; Aza Analogs of Flavanones
- The proliferation and differentiation of neural stem cell from mouse embryonic forebrain
- Anti-cancer activities of Favonoids in Hep3B and SK-Hep1
- Synthesis and Evaluation of 5,8-quinoxalinediones as Vascular Smooth Muscle Cell Proliferation Inhibitor
- Synthesis and In vivo evaluation of Selenoflavanone : A New class of Neuroprotective agent
- C-Reactive Protein Induces Apoptosis in Human Monocytic Leukemia Cells
- Development of in silico prediction model for hERG protein binding activity
- A New Method for Macrodiolide Formation Using Selenol Ester
- Synthesis and Antibacterial Activity of DW-224a, A New Fluoronaphthyridine Antibiotic
- In silico screening approach for hit identification of GSK-3β inhibitors
- Synthesis of new apicidin derivatives as potent histone deacetylase inhibitors (HDAC)
- Establishment of a Cisplatin-Resistant Gastric Carcinoma Cell Line YCC-3/R
- EK-6136, (3-M ethyl-4-(O-methyl-oximino)-1-phenylpyrazolin-5-one): A novel Cdc25B inhibitor with antiproliferative activity
- Discovery of Novel Ligands for RNA Pseudoknot of SARS Coronavirus by Virtual Screening and -1 Ribosomal Frameshifting Assay
- Synthesis of 1,8-naphthyridins as anticancer agents
- Development of Synthetic Methodology for Furofuran Lignans
- Inhibition of CDK2 activity by dehydrocostuslactone and costunolide
- Effect of Streptococcus pneumoniae adh mutation on gene expression in the A549 cells
- in silico Screening Approach for Hit Identification of PTP1B Inhibitors
- Structure-Activity Relationship Study of Gentisic Acid Esters as Potential Skin Whitening Agents
- Synthesis and antifungal activity of 5-arylamino-4,7-dioxobenzo[b]thiophenes
- Design and Synthesis of D-4'-Thioadenosine derivatives as ultrapotent and selective agonists at the human A₃adenosine receptor
- Safety assessment of potential lactic acid bacteria Bifidobacterium longum SPM1205 isolated from healthy Korean in SD rats
- Total synthesis of Apiddin A and side chain modified Derivatives as Potent Antitumor Agents
- Rac pathway is critical for capsaicin-induced apoptosis of H-ras-transformed human breast epithelial cells through ROS generation
- Asymmetric synthesis of novel thioiso dideoxynucleosides with exocyclic methylene as potential antiviral agents
- New antibiotics of the nocardamine class from a marine-derived Streptomyces sp.
- Superior antitumor efficacy of Genexol?-PM, a biodegradable polymeric micelle-based formulation of paclitaxel (Genexol?) compared with Gemcitabine and Taxol in human pancreatic cancer
- Cardioprotective effect of KR-32560, a novel sodium/hydrogen exchanger-1 inhibitor, on ischemia/reperfusion heart injury in rat
- Korea Red Ginseng Water Extract Increases Nitric Oxide Concentrations in Exhaled Breath
- Anti-Oxidative compounds of Polygonum multiflorum Aerial Parts
- Anticancer Effect and Gene Expression Regulation of Major Constituent of Green Tea, EGCG in Gynecologic Cancers
- Characterization of Recombinant Human Growth Hormone loaded Phosphazene Formulation as Injectable Drug Delivery System
- Contribution to the anti-inflammatory potential of sulfuretin isolated from the heartwood of Rhus verniciflua through down-regulation of IκB kinase and NF-κB activation in macrophages
- Simultaneous Chiral Discrimination of β-Blockers as Diastereomeric N-(-)-Menthoxycarbonylated O-Trimethylsilyl Derivatives by Achiral Gas Chromatography
- Reversal of multidrug resistance by benzotriazepin analogues in cancer cells (Ⅱ)
- Safety and Efficacy Assessment in Cell and Gene Therapy Products : Today's Thinking for Tomorrow's Success
- Toward a Therapeutic Application of Artificial Transcription Factors
- Monoamine Oxidase Inhibitory Components from the aerial parts of Dictatnnus albus
- Potent and Selective Inhibitors of CDK2 as antitumor Agents: Synthesis, SAR Analysis, and Biological Activity
- Diastereoselective Synthesis of Unsaturated 1,2-Amino Alcohols from α-Hydroxy Allyl Ethers Using Chlorosulfonyl Isocyanate
- Capacitative Calcium Entry Is Involved In Regulation of Muscarinic Stimulation of Nf-Kb Mediated Sappa Release
- Five oleanene-triterpene glycosides from the leaves of Acanthopanax sieboldianus
- Therapeutic concentration of antipsychotic drugs in patients of psychiatric disorders
- Risk Analysis of Drug Adverse Reaction: in Case of PPA
- Anticancer constituents with topoisomerase inhibitory activity from the roots of Rubia cordifolia L.(Ⅱ)
- The effects of dietary flavonoids on the benzo(k)fluoranthene-induced CYP1A1 gene expression
- Down-regulation of murine CYP1A1 in mouse hepatoma hepa-1c1c7 cells by biochanin A
- Inactivation of the Erk1/2 Pathway by Map Kinase Phosphatase-1 Mediates Hydrogen Peroxide-Induced Cell Death in Sh-Sy5y Cells
- A new conceptional double staining for protein in SDS-PAGE using azo dye as silver ion sensitizer
- Immune-Enhancing Effect of Mountain Grown Ginseng
- The docked models of COX-2 inhibitors
- The 3D-QSAR Study of Quinoline Derivatives with Antifungal Activity by CoMFA
- The protective effect of methanol extracts from Acanthopanax koreanum Nakai against skin aging
- NF-κB inhibitors from Artemisiae asiaticae Herba
- Quantitative Analysis of Commercial Herbal Medicines and study on identification method by LC/MS
- 1. Cytotoxic activity of 1,8-naphthyridins derivatives
- Sensitive Determination of Pinaverium Bromide in Human Plasma by LC-ESI-MS/MS : Applicability to Oral Bioavailability Determination
- Protective effects of Gingko biloba Water Extract on the ischemia induced 4-vessel occlusion and cognitive impairments in the rat
- Quality evaluation of Saussureae Radix by HPLC
- Discovery of P-glycoprotein Modulators from Natural Products
- Simple method for preparation of active S-(-)- bisoprolol
- KFDA Implementation Policy of KDMF
- Inhibitory effects of xanthorrhizol on LPS-induced nitric oxide (NO) production and human cancer cell proliferation
- Stereoselective Formal Total Synthesis of Trehazolin
- Increase in Intracellular Calcium mediates dopamine release through the production of ceramide via Sphingomyelin Pathway in PC 12 cells
- DW1350, a Newly Synthetic Anti-osteoporotic Agent : 4. Effect on Ovariectomized and Neurectomized Osteoporosis Mice Model, a Histomorphometrical Aspect
- Safety test of chitosan oligosaccharide in Mice : Micronucleus and chromosome aberration test
- Proteomic analysis of synaptic vesicle from rat brains
- p43, a cofactor of tRNA synthetase, enhances T helper type 1 response by inducing interleukin-12 production in macrophages via NF-κB activation
- New Bisindole Alkaloids from the Marine Sponge Spongosorites sp.
- Anti-gastritic effect and cytotoxicity of Amomum villosum
- Regulation of Fumonisin B1-induced toxicity by sphingolipid methabolism
- Determination of itraconazole in human plasma by high-performance liquid chromatography with UV detection
- Development of liquid chromatographic method for determining melilotus extract in pharmaceutical preparations
- Biomimetic Micro-Nano fibrous scaffold for chondrocyte culture
- Therapeutic Effects of the Preparation of Lithospermi Radix and Gardeniae Fructus Extracts on the Burn and Wound Healing
- Study on Polymorphism of DA-6034
- Rapid Screening of Drug Blood-Brain Barrier Permeation Potential Using the Immobilized Artificial Membrane Phosphatidylcholine Column and Molar Volume
- Inhibition of prostaglandin production by a structurally-optimized flavonoid derivative, 2',4',7-trimethoxyflavone and cellular action mechanism
- CAP: Evaluation of risk factors for hospitalization and comparison of empiric regimens for efficacy and toxicity
- 19α-Hydroxyursane-type Triterpenoids, Antinociceptive Anti-inflammatory Principles of the Roots of Rosa rugosa
- Constituents from the stems of Parthenocissus tricuspidata and their DNA topoisomerases I andⅡinhibition and cytotoxicity
- Process Analytical Technology (PAT) for Pharmaceutical Industries
- Anti-obesity effect of STB-BM (mineral complex containing rare earth elements) in rats fed high fat diets
- Silibinin, A Major Active Component of Silymarin, Inhibits Rabbit Platelet Aggregation
- 15-Deoxy-Δ¹²,¹⁴-Prostaglandin J₂Protects Against Nitrosative PC12 Cell Death through Up-reguiation of Intracellular Glutathione Synthesis
- TNFα -308 and TNFβ +252 locus plays an important role in the etiopathogenesis of cerebral infarction
- The Studies on the Quality Control and the Revision of Acanthopanacis Cortex Monograph in Korean Pharmacopoeia
- Euonymus alatus prevents the onset of high-fat diet induced hyperglycemia in ICR mice and improves insulin resistance in C57BL/6J ob/ob mice
- Anti-inflammatory mechanism of benzoxathiol LYR-64 compound in LPS-stimulated macrophages RAW264.7
- Distinguishment of two polymorphic forms (Q&R) of Paraoxonase1 by Linoleic acid
- Ca2+Signaling in Atrial Myocytes: Evidence from 2-D Rapid Confocal Imaging
- Safety Evaluation of Biotech-derived Pharmaceuticals such as Papillomavirus Recombinant Vaccine Candidate
- p-85 beta PIX is necessary for cell motility via focal adhesion kinase phosphorylation
- Characterization of a Novel Calcium-independent Phospholipase A₂in Bovine Brain
- N-4-Substituted-benzyl-N'-tert-butylbenzyl Thioureas as Vanilloid Receptor Ligands : Investigation on the Role of Methanesulfonamido group in Antagonistic Activity
- Identification of rat syncytiotrophoblast Ⅰ,Ⅱ specific genes using conditionally immortalized syncytiotrophoblast TR-TBTs cell lines
- Identification of +1 Ribosomal Frameshifting site of Leishmania RNA virus by mutation analysis
- Anti-psoriatic Activity of Chunghyuldan on Oxazolone-induced Contact Dermatitis in Mice
- Deproteinization of Plasma Sample by Solld-Phase Extraction in Gel Filtration Mode using Sephadex G-10 Column
- Preparation and characterization of solid lipid nanoparticles (SLNs) containing paclitaxel
- Characterization and carbohydrate binding specificity of lectin isolated from Maackia fauriei
- Bioequivalence of Bendipine™ Tablet to Codipine™ Tablet (Benidipine Hydrochloride 4 mg)
- Impact of CYP2C9 polymorphism on Flurbiprofen pharmacokinetics in healthy Korean population
- Haplotype analysis of the MDR1 (exon 12, 21 and 26) genes in Korean population and no effect of the MDR1 haplotypes on sparfloxacin disposition
- E7-Expressing HaCaT Keratinocytes Are Resistant to Oxidative Stress-Induced Cell Death via Induction of Catalase
- Human Papillomavirus Vaccines in Preclinical Development
- A Fatal Case related to DDS Intoxication
- New Lignans with Antioxidant Activity from the Stem Bark of Styrax japonica
- Pharmacognostical Studies on the Dang Gui from Korea
- Construction and expression of a single-chain Fv fragment against berberine in Escherichia coli
- Hair growth effect of Biota orientalis extract
- Determination of Tectochrysin in the Korean Propolis by HPLC
- Simultaneous determination of niflumic acid and its prodrug, talniflumate in human plasma by high performance liquid chromatography
- Rapid and Sensitive Determination of Oxiracetam in Human Plasma by LC/MS/MS
- Analysis of acanthoic acid and isomers in Acanthopanax species
- Pharmacokinetic study of cefprozil diastereomers in human plasma by high performance liquid chromatography
- Overexpressing porcine IL-18 genes in porcine kidney cell induces mouse anti-pig cellular rejection in cellular xentransplatation
- The oligosaccharide analysis of sialylated glycoproteins using a high-performance liquid chromatography
- Preparation and Characterization of Chitosan adsorbed Solid Lipid Nanoparticles containing 7-Dehydrocholesterol
- Dexamethasone ameliorates peritoneal ascites, but has no therapeutic advantages in liver fibrosis
- Prediction of human pharmacokinetics of apicidin by using physiologically-based pharmacokinetic model
- Design and synthesis of non-peptide bradykinin antagonists and evaluation of their inhibitory activity on guinea-pig ileum contraction
- New meroditerpenoids from a marine brown alga Sargassum sp.
- Antioxidant Activity of Pine (Pinus densiflora Sieb. et Zucc) : Scavenging Activity against Superoxide Radical and 1,1-diphenyl-2-picrylhydrazyl(DPPH) Free Radical
- Activation of MKK6 Induces Invasive and Migrative phenotypes in MCF10A Human Breast Epithelial cells
- Development of method for improving extraction efficiency of D-amygdalin in Ma-whang tang as traditional oriental preparation
- NMR spectroscopy and pattern recognition methods for metabolic urinalysis of experimental animals
- The Studies on the Establishment of Correct Identity and Features of Acanthopanacis Cortex
- Total synthesis of (-)-Anisomycin
- Astrocyte activation-dependent neuronal cell differentiation by erythropoietin
- Metabolism of an anti-inflammatory propenone compound in rat liver microsomes
- Novel g-Lactam base Histone Deacetylase (HDAC) Inhibitors : Synthesis and Biological Evaluation
- Drug Design for Genome Targeting
- Regulation of Immunomodulating Gene Expression in RAW264.7 Murine Macrophage by Taurine
- Inhibitory Effect of Saenghyulyeunbueum-Ghami on Mast Cell-Mediated Allergic Inflammatory Reactions
- The investigation of biologically active compound from Protaetia brevitarsis larva
- Growth Inhibitory and Apoptotic Effect of Linarin Acetate on Human Prostate Carcinoma Cells
- Enantioseparation of levodopa for quality evaluation
- Quality evaluation of Acanthopanax species by CE
- HPLC determination and phalmamkinetic profile of Talniflumate in Korean volunteers
- Pharmacokinetics of Heptaplatin combined with 5-FU : Phase Ⅰ/Ⅱ Clinical Trial against Head and Neck Cancer
- Emulsion lyophilization technique suitable for improved loading of hydrophilic drugs into solid lipid nanoparticles
- Apoptosis induced by novel quinoline compound, KYS-50248 in HL-60 human promyelocytic leukemia cells through death receptor and mitochondrial pathway
- Three new alkaloids from Aconitum pseudolaeve var. erectum
- Protective agents against sepsis from the root of Saururus chinensis
- Phytochemical Constituents of Rhododendron brachycarpum
- Anti-stress Effect of extract mixed with Schizandra chinensis and Scutellaria baicalensis
- Cytotoxic Chalcones from Chinese Licorice
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