학술논문
SB-Injection, an anticancer agent prepared from the roots of
이용수 11
- 영문명
- 발행기관
- 대한약학회
- 저자명
- Byung-Zun Ahn
- 간행물 정보
- 『춘계총회 및 학술대회』(2005년) vol.1, 63~64쪽, 전체 2쪽
- 주제분류
- 의약학 > 내과학
- 파일형태
- 발행일자
- 2005.04.30
무료
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이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
In a medicinal practice in Puyeo, Chungnam /Korea, a preparation made from the roots of
Pulsatilla koreana, Panax ginseng and Glycyrrhiza glabra has been used to treat various cancers. It
was previously reported that SB31 , a preparation consisting of the extracts from the roots of
Pulsatilla koreana, Panax ginseng and Glycyrrhiza glabra, exhibited cytotoxic activity against some
human cancer cell lines (Kim et a/., 1994, 1995), and potent antitumor activity on ICR mice bearing
S (sarcoma)-180 cells (unpublished data).
We are going to present the R&D procdures includjng the measurement of antitum or activity,
isolation of main antitumor component as well as the results of the preclinical and phase I clinical
studies.
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- Relationship of Osteoporosis and oxidative stress; levels of urinary 8-isoPGFja decrease in Osteoporosis
- "The deguanilation of guanine-based nucleosides by the incubation of 2-bromopropane or other structurally related halogenated alkanes at the physiological condition"
- Biarylcarboxybenzamide derivatives as Potent Vanilloid Receptor Antagonistic Ligands
- Some compounds from the fruit of Hovenia acerba
- Activation of MAP Kinase Kinase (MKK)-6 Induces MMP-2 Upregulation Leading to Invasive Phenotype of Breast Epithelial Cells
- Syntheses and SAR of Substituted 1,1^-Diaminoketones as Candida albicans GGTase Type-I Inhibitors
- Ginsenoside R pl, a ginsenoside of major metaboiite, as a new Immunomodulatory regulator.
- Quantitative Aniaysis of Itraconazole in Human Plasma by Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry.
- Determination of 3-chloro-l,2-propanediol in water by GC/MS
- Quaility monitering of Oriental Medicine
- Antinociceptive Antiinflammatory Effect of Monotropein Isolated from Morinda oifkinulis
- Resistance to Cethromycin Conferring Constitutive Resistance to Macrolides in Staphylococci
- The dextromethorphan analogue dimemorfan attenuates kainite-induced seizers via a l receptor activation: comparison with the effect of dextromethorphan
- Enantiomer Separation of Amino Acid Esters as Benzophenone Imine Derivatives Using Polysaccharide Derived Chiral Stationary Phases
- Vasorelaxant activity of the root extract of Rheum undulatum on the contractility of rat aorta
- Skin Permeation and Analgesic & Anti-inflammatory Effects of Ketorolac tromethamine Preparations Containing Menthol.
- Antimicrobial and Antioxidant Activities of Nepalese Medicinal Plants
- Anti-diabetic effect of Cariolus versicolor in mice
- Lactic acid bacteria as oral antigen protein carriers
- Evaluation of bioequivalence of propiverine tablet in healthy volunteers
- Structure and Biological Activity of Phenolic Compounds
- The cleavage of Cdc6, replication factor by caspase 3 promotes and induces apoptosis
- Optimization of informative spectral regions for the quantification of blood components using searching combination moving window partial least squares method with near infrared spectroscopy
- Achiral and Chiral Analysis of Multiple p-Blockers by Achiral Gas Chromatography
- Highly Sensitive Determination of Lacidipine in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry.
- Monoacyl lipoteichoic acid from pneumococci stimulates human cells but not mouse cells.
- ADME Prediction in Drug Discovery: Predictability Evaluation of Various ADME Prediction Softwares
- Antiproliferative Activity of a Novel S-lactam Base Histone Deacetylase Inhibitor via Selective Gene Expression
- Determination of isotretinoin in human plasma by high-performance liquid chromatography with ultraviolet detection
- Column-switching high-performance liquid chromatographic analysis of fluvastatin sodium in rat plasma by direct injection
- Isoflavonoid from Viola hondoensis, regulates the expression of matrix metalloproteinase-1 in young aged human skin flbroblasts
- Development of mobile phase with fluorescence in sugar analysis by HPLC
- Genetic polymorhisms of the MDRl genes and pharmacokinetics of losartan in healthy Korean subjects
- Molecular characterization of a lectin from Maackia fauriei
- Comparison of Two Different Extended Release Formulations of Venlafaxine in Healthy Male Volunteers
- Co-incorporation of antioxidants enhances the stability of all-trans retinol loaded in solid lipid nanoparticles
- Development of a capillary electrophoretic method for enantioseparation of tiropramide.
- Study of chitosan oligosaccharide on human kidney cell by MTT assay and LDH assay
- Topical gene delivery to the skin using cationic solid lipid nanoparticles
- Pharmacokinetic changes of enoxacin in uranyl nitrate-induced acute renal failure (U-ARF) rats
- Anti-Oxidative, Nitric Oxide and ProstaglandinEi Production Inhibitory Activities of Phenolic Compounds from the Seeds of Primus tomentosa Thunberg
- Metabolic inhibition of an antiestrogen by pharmaceutical excipients in human liver microsomes
- Apoptosis-accelerating activity of CYPIBI inhibitor 2,4,3'5'-tetraniethoxystilbene in HL-60 cells
- Point to consider on the efficacy and safety evaluation in dendritic cell immunotherapy
- Evaluation of the stability of TNF-related Apoptosis Inducing Ligand.
- Gas Chromatographic Profiling Analysis of Amines and Phenols for Clinical Applications
- A New Cytotoxic Compound of the Methylpyridine Class from a Marine-derived Streptomyces sp.
- Genetic polymorphisms and haplotypes of MDRl gene (exon 12, 21 and 26) in Korean population
- IdentiHcation of -1 Ribosomal Frameshifting Site of Borrelia burgdorferi B31 by Mutation Analysis.
- Metabolism of Ginsenoside Re by Human Intestinal Microflora and Their Estrogenic Effects
- The Pharmacokinetic Study of Fenoterol hydrobromide in Korean Healthy Volunteers by LC-ESI/MS/MS
- Inhibitory mechanism of novel benzoxathiol LYR-64 compound on IL-6 production in LPS-stimulated macrophages
- Supercritical carbon dioxide extraction of Abies koreana W. essential oil
- Subacute Oral Toxicity of Phenol derivative(MS) from Cordyceps militaris
- Enhancement of dissolution rate and bioavailability of amlodipine using spray-dried microspheres
- Highly Enantioselective Synthesis of (R)-a-Alkylserines via Phase-transfer Catalytic Alkylation of o-biphenyl-2-oxazoline-4-carboxylic acid tert-butyl ester using Cinchona derived catalysts
- Benzoxathiol LYR-64 compound down-regulates iNOS expression by preventing JAK2 activation in IFN-gamma-stimulated macrophages
- Effect of pharmaceutical excipients on chemical stability of proton pump inhibitor
- Formal synthesis of Lepadiformine.
- Transdermal delivery of low molecular weight heparin with ultraflexible liposomes
- Quantitative analysis of gabapentin in human plasma by gas chromatographymass spectrometry
- Cytotoxic activity of thioureido ceramide derivatives
- A dibenzyl-g-butyrolactone lignan from the stem-bark of Styrax japonica
- Isolation and Biological Activity of Sesquiterpene Lactone
- Study on Staminal Activities of the extracts of Watermellon and octacosanol
- Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide and cyclooxigenase-2 by chiisanoside via suppression of nuclear factor-KB activation in RAW 264.7 macrophage cells
- Modulation of macrophage functions by fractions containing proteinpolysaccharide complex from Lentinus edodes
- Purpureaside A, a glycoside isolated from Digitalis purpurea inhibits the induction of nitric oxide synthase through the blocking of AP-1 activation
- Anti-stress effects of the ginsenosides Rg3 and R bl on the changes in brain polyamine levels after immobilization stress
- Immunostimulating activity of Cariolus versicolor to activate macrophages in mice
- Determination of ranitidine in human plasma by high-turbulent liquid chromatography with ultraviolet detection
- Anti-Oxidative Effects of Quercetin-Glycosides Isolated from the Flower Buds of Tussilago farfara L.
- Effect of ochnaflavone, naturally occurring biflavonoid, on inflammatory response
- Dissociation in Characteristics of Tetraethylammonium Distribution to the Kidney Cortex and Kidney Medulla in Acute Renal Failure: Involvement engodenous effects to Organic Cation Transporter 2
- Pharmacokinetic interaction between verapamil and naringin in Rabbits
- Separation and Stability of Positional Isomers of PEGylated Somatostatin Analogue
- Educatonal effects of the drug abuse prevention program based ont the National Survey on the drug abuse in Korea
- Identification of Ym2 gene in mouse bone marrow-derived mast cells by IL-4 and expression of Ym2 protein by HEK 293 cells
- A lectin from coastal crab Macrophthalmus Japonicus
- Anti-Fatigue Effect of Lactic acid bacteria (Lactobacillus acidophilus,Bifidobacterium bifldum, Streptococcus thermophilus) in ICR Mice
- Sialic acid derivative-binding protein from Cordyceps militaris
- A pharmacological advantage of Ursodeoxycholic Acid in cytoprotection in primary rat microglia.
- A potent anti-complement activity of acylated sterol glucoside from Orostachys japonicus
- Antioxidative Effect of Epimedium koreanum in Ovariectomy.
- Broad-spectrum antioxidant peptides derived from His residue-containing sequences present in human paraoxonasel.
- Production of TNF-a and IL-2 by PBMC in vitro incubation with flavonoids
- Levels of urinary 3-hydroxy fatty acids increase in hyperthyroidism using gas chromatography-mass spectrometry
- Antioxidant activity of several subfractions from the extract of CBN-1 and KG
- Hypoxia-induced IL-6 production is associated with activation of MAP kinase,HIF-1, and NF-kB on HEI-OCl cells
- Anxiolytic-like effects of Phyllostachys nigra in mice
- Syntheses and Cytotoxicity Test of Quinobenzoxazine Analogues
- Intracellular Accumulation of ID-6105 in Ovarian Cancer Cell Line
- Preparation and Characterization of Lysozyme Nanoparticles using solution enhanced dispersion by supercritical fluid (SEDS) Process
- Antioxidant Activity of Smilacis Chinae Radix
- Regulatory Mechanisms and Their Therapeutic Implications of IL-12/IL-4 Production in T Helper Cell Differentiation
- Protective Effect of (S)-Bakuchiol from Psoralea corylifolia on Rat Liver Injury In Vitro and In Vivo
- Anti-Diabetic Effects of DY-101357, A Potent PPARs Agonist
- Anti-inflammatory Effects of Morinda citrifolia Extracts in Skin-incised Mice
- PHOTOSTABILITY STUDY OF AMLODIPINE PRODUCTS
- Inhibition of TGFpi-mediated PAI-1 induction by oltipraz through selective interruption of nuclear transport of Smad 3/Smad 4
- Anti-cancer effect of STB-HO (mineral complex containing rare earth elements) in nude mice transplanted human lung cancer cells
- Detection and identification of Mycobacteria by PCR-RFLP
- The Pharm acisfs Role in SigniHcant Hazardous Interactions of Duplicative Therapy Focusing Antipsychotics and Antibiotics for Drug Utilization Review
- The Anxiolytic-like Effects of Cinnamomum Cassia Related with 5 -H T ia and GABAa receptor in the Elevated Plus Maze
- Anti-diabetic Drug Development from Natural Resources
- Growth hormone booster attenuates memory impairment and oxidative stress in the genetic model of aging gene klotho mutant mice
- Hepatobiliary Transport of IH-901, a Potential Anticancer Agent, in Freshly Isolated and Sandwich-Cultured Rat Hepatocytes
- Rheological, mucoadhesive and release properties of thermosensitive gels for the treatment of hemorrhoids
- Apoptotic potential of ergolide, a sesquiterpene lactone from Inula britannica var chinensis
- Effect of 4-lBBL on the DC induced T cell activation : in vitro dose-dependency.
- IN2001 is a Novel Histone Deacetylase Inhibitor with Potent Antitumor Activity against Breast Cancer in Vitro and in Vivo.
- Regulation of Tissue-Specific Gene Expression by Dynamic Change in Histone code
- Studies on the Constituents of Ostericum koreanum
- Determination of cinnamic acid and cinnamaldehyde in crude drugs by HPLCPDA
- Studies on development of a HPLC method to measure content recombinant interferon alpha-2
- No relationship between genetic polymorphisms in CYP2D6 and MDRl and cilostazol pharmacokinetics
- Pharmacokinetics of Amikacin in Korean Premature Infants
- DA-8159, A New Erectile Dysfunctional Drug
- Recent Technologies in Drug Delivery System
- Involvement of mutant presenilin 2 in the abnormality of lipid metabolism in developing Alzheimer^s disease
- In vitro peroxynitrite scavengers and two new biflavone glucosides from Ginkgo biloba leaves
- Solid-Phase synthetic method for racemic and Non-natural a-Amino Acids via Phase-Transfer Catalytic alkylation
- Inhibition of the induction of nitric oxide synthase by amentoflavone in macrophages
- Enhanced Oral Bioavailability of Genistein Formulated into Solid Lipid Microspheres
- Determination of carbamazepine by high-performance liquid chromatography in human plasma.
- Isolation of Saponins with the Inhibitory Effect on Nitric Oxide Formation from Pleurospermum kamtschaticum
- Effect of DW1350 on Acute Inflammation: Xylene-Induced Ear Acute Inflammation Mice Model
- Anti-Oxidative and Nitric Oxide Production Inhibitory Effect of Extract and Fractions from the Barks of Actinidia arguta
- A novel mechanosensitive channel identifled in sensory neurons
- Cardiopreotective effects of KR-32570, a novel N aM i수 exchanger inhibitor, in rats and dogs
- Determination of Ethambuto! in Human Plasma by a Validated HPLC Method and Its Application to Single-dose Pharmacokinetics
- KR-32560, a novel NHE-1 inhibitor exerts cardioprotective effects via reduction of oxidative stress in a rat model of ischemia/reperfusion-induced heart injury
- Effects of DA9102 on Dermatosis in magnesium-deficient hairless rats
- Effect of some herbal extracts'* mixture on postmenopausal urinary incontinence in ovariectomized rat.
- Effect of Ginsenoside Re and Its Metabolites Ginsenoside Rgl and Ginsenoside Rhl in Chronic Oxazolone-lnduced Mouse Dermatitis
- Enantioselective Synthetic Method for a-Alkylserine via Phase-Transfer Catalytic alkylation of 2-phenyl-2-oxazoline-4-carbonylcamphorsultani
- Deoxysulfamate Analogues of Methionyl and Isoleucyl Adenylates as Inhibitors of Methionyl-tRNA and Isoleucyl-tRNA Synthetases
- Identification of polyunsaturated fatty acid with anti-inflammation activity from the fruit of Actinidia polygama
- Determination of venlafaxine in human plasma by high-performance liquid chromatography with ultraviolet detection
- Oxidative cyclization of chalcones
- p-85 beta PIX differentially regulates cell motility via FAK and p38 MAP kinase phosphorylations
- 3D-QSAR study of 3 and 4-substituted cephems with HLE Inhibitory activity
- The effects of C. annuum L. leaf on cancer cell lines and the Mouse
- Regulation of Dendritic Spine Morphogenesis by PSD-95
- Introduction to The Concept and Practice Guideline of Drug Utilization Review
- The role of peroxiredoxin (Prx) I I in the kainic acid (KA)-induced neurotoxicity
- The finding of novel neutral Magnesium independent form Smase
- Current Evaluation of Biochips in KFDA
- Virtual Screening and Ligand Optimization for The Development of Novel Aminoacyl-tRNA Synthetase Inhibitors
- IdentiHcation and Functional Study of a Novel Form of 60kDa Mg dependent Neutral Sphingomyelinase
- Production of Recombinant hGM-CSF in Plant Cell Suspension Culture
- Acid induces COX-2 expression via ERK and p38 MAPK activation in cultured cat esophageal smooth muscle cells
- Psoralen derivatives block hKvl.5 Current
- Statistical Concepts in Bioequivalence Studies
- Positive improvements of climacteric symptoms by isoflavones extracted from Sophorae fructus, in ovariectomized Sprague-Dawley rats.
- The expectorant effect of Dioscorea quinqueloba component
- Cellular uptake and transfection efficiency of plasmid DNA using low molecular weight polyethylenimine
- Insulin Signaling in Regulation of Drug Metabolizing and Antioxidant Enzyme Expression
- Drug Interactions and Medication Teaching in Concurrent use of Herbal Medicines and Pharmaceutical Drugs
- Assurance of Food Safety: Food Xenochemicals
- Age-specific Contraindication of Therapeutics
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