정상안압녹내장에서 당뇨 유무에 따라 분석한 안토시아노사이드, 은행잎추출물의 치료 효과

• 영문명: The Effect of Anthocyanoside and Ginkgo Biloba Extract on Normal-Tension Glaucoma According to Presence of Diabetes
• 발행기관: 대한안과학회
• 저자명: 이용우 최철영 배정훈 김준모,Yong Woo Lee, MD, Chul Young Choi, MD, Jeong Hun Bae, MD, Joon Mo Kim, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number8, 1174~1179쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.08.15

영문 초록

Purpose: This study was performed to evaluate the effect of anthocyanoside and ginkgo biloba extract (GBE) in patients with normal tension glaucoma (NTG), according to the presence of diabetes mellitus (DM). Methods: A chart review of patients with normal tension glaucoma was retrospectively analyzed. All patients underwent a Humphrey visual field (HVF) test and logarithm of the minimal angle of resolution best-corrected visual acuity (log MAR BCVA) was measured over a 6 months period. Changes in mean deviation (MD), pattern standard deviation (PSD) of visual field and log MAR BCVA were compared among anthocyanoside, GBE and no medication (control) groups. Patients were divided according to the presence of DM. Results: A total of 406 NTG patients, including 151 DM patients, were included in the present study. MD was improved in the anthocyanoside and GBE groups, but not in the control group. PSD was not significantly different in all groups. BCVA was improved in the anthocyanoside group, but deteriorated in the control group. The results were similar in patients with or without DM. The generalized linear model demonstrated that systemic medication affected changes in visual indices. Conclusions: The results from the present study suggest that anthocyanoside and GBE may be helpful for improving visual function in some patients with NTG regardless of their DM status. J Korean Ophthalmol Soc 2014;55(8):1174-1179

키워드

Anthocyanoside, Diabetes mellitus, Ginkgo biloba extract, Normal tension glaucoma