반복된 단순포진 각막염의 반흔에 발생한 포마 그로메라타 진균각막염 1예

• 영문명: A Case of Phoma glomerata Keratitis Occurred in Recurrent Herpes Simplex Keratitis Cicatrix
• 발행기관: 대한안과학회
• 저자명: 전종화 류남희 장성동,Jong Hwa Jun, MD, Nam Hee Ryoo, MD, Sung Dong Chang, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number8, 1229~1232쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.08.15

영문 초록

Purpose: To report a case of Phoma glomerata keratitis occurring in recurrent herpes simplex keratitis cicatrix. Case summary: A 63-year-old male patient was admitted to our hospital with complaints of abrupt visual deterioration and ocular pain in his left eye. He was treated for recurrent herpes simplex keratitis in the same eye 12 years prior. Because central desmatocele was observed as a result of advanced corneal stromal melting, Gram staining, Potassium Hydroxide (KOH) mount, and culture were performed in corneal scrape specimens. On microbiological evaluation, a Phoma species was detected and Phoma glomerata was diagnosed using DNA sequencing method. Two consecutive amniotic membrane transplantations were performed with topical antifungal agents. The lesion was not improved when using topical amphotericin B and natamycin eyedrops, thus fluconazole eyedrops were used additionally. The corneal infection was resolved with central thick opacification. Conclusions: In the present case, herpetic keratitis was the main underlying causative factor because the patient had no past history of trauma. When diverse appearances of keratitis occur in herpes simplex keratitis patients, clinicians need to consider the concurrence of fungal infection, especially Phoma glomerata, a rare fungal organism. J Korean Ophthalmol Soc 2014;55(8):1229-1232

키워드

Cicatrix, Herpes simplex, Keratitis, Phoma glomerata, Recurrent