항암치료를 위해 사용된 표피성장인자 수용체 억제제로 유발된 긴속눈썹증 2예

• 영문명: Paradoxical Trichomegaly of the Eyelashes During Treatment with EGFR Inhibitors: 2 Case Report
• 발행기관: 대한안과학회
• 저자명: 나건후 엄영섭 강수연 김효명 송종석,Kun Hoo Na, MD, Young Sub Eom, MD, Su Yeon Kang, MD, Hyo Myung Kim, MD, PhD, Jong Suk Song, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number6, 908~912쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.06.15

영문 초록

Purpose: To introduce 2 cases of trichomegaly associated with the use of systemic epidermal growth factor receptor (EGFR) inhibitors for the treatment of lung cancer. Case summary: An 82‐year‐old female visited our clinic for ocular pain in both eyes. She was suffering from metastatic lung cancer and was under daily treatment with gefitinib (Iressa^{®, AstraZeneca, London, UK) for 6 months. On ophthalmologic examination, she presented with abnormally elongated eyelashes, hyperemic conjunctiva and dense corneal erosion. A 52‐year‐old male who was diagnosed with non‐small cell lung cancer 7 months before and treated with erlotinib (Tarceva® OSI Pharmaceuticals, Inc., Melville, NY, USA) was referred to our clinic for injection and foreign body sensation in both eyes. Although there were no remarkable changes in eyelashes at the initial visit, long, curly, uneven eyelashes were observed after 3 months. Conclusions: Due to the increased use of EGFR inhibitors in anti‐cancer treatment, ophthalmologists should be aware of these chemotherapeutics' adverse effects. J Korean Ophthalmol Soc 2014;55(6):908-912}

키워드

Epidermal growth factor receptor inhibitor, Trichomegaly