스테로이드 무반응 시신경척수염 환자에서 혈장분리교환술의 효과

• 영문명: Efficacy of Plasma Exchange Therapy for Steroid-Unresponsive Neuromyelitis Optica
• 발행기관: 대한안과학회
• 저자명: 조성호 최재환 최희영 정재호,Seong Ho Jo, MD, Jae Hwan Choi, MD, Hee Yonng Choi, MD, PhD, Jae Ho Jung, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number3, 465~472쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.03.15

영문 초록

Purpose: To report the therapeutic efficacy of plasma exchange therapy on steroid-unresponsive neuromyelitisoptica (NMO) patients. Case summary: Three patients who had not achieved improvement of visual acuity and visual field after high steroid pulse therapy after optic neuritis visited our clinic with decreasing visual acuity combined with eye pain in the other eye. All patients were diagnosed as neuromyelitisoptica (NMO) based on the presence of NMO-IgG antibody and optic nerve enhancing in contrast-enhanced orbital magnetic resonance imaging (MRI). Recurrent optic neuritis was observed. Steroid pulse retreatment was started but visual acuity was not improved in all patients. The patients received plasma exchange therapy, followed by immune suppression therapy. All patients showed improved visual acuity and restored visual field promptly without recurrence of neuromyelitisoptica. Conclusions: In case of steroid-unresponsive neuromyelitisoptica, plasma exchange should be promptly considered as the treatment of choice. J Korean Ophthalmol Soc 2014;55(3):465-472

키워드

Neuromyelitisoptica, Plasma exchange, Steroid pulse therapy