중증도에 따른 아벨리노 각막이상증의 공초점주사현미경 소견

• 영문명: Confocal Microscopic Findings of Avellino Corneal Dystrophy According to Disease Severity
• 발행기관: 대한안과학회
• 저자명: 박영민 김호윤 이종수,Young Min Park, MD, Ho Yun Kim, MD, Jong Soo Lee, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number3, 361~367쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.03.15

영문 초록

Purpose: In this study we analyzed and objectified the characteristics of the Avellino corneal dystrophy patients considering disease severity using in vivo confocal microscopy (IVCM). Methods: Each corneal layer of 36 eyes in 18 patients with Avellino corneal dystrophy was examined using IVCM (ConfoScan 4.0, NIDEK, Co. Ltd., Albignasego, Italy). Patients were classified into 3 groups based on disease severity (mild, moderate, or severe). Results: In the mild group, hyper-reflective granular deposits without dark shadows were observed in the anterior stroma. As the disease progressed, corneal deposits were also found at the posterior stroma and epithelium, and clusters of hyper-reflective corneal deposits resembling stromal opacity were noted. The range of corneal deposits measured using Z-scan optical pachymeter was 111.14 ± 30.95 um in the mild group, 157.47 ± 25.00 um in the moderate group, and 193.42 ± 52.23 um in the severe group (p < 0.05). Conclusions: The origin of the corneal deposits in Avellino corneal dystrophy may be related to corneal stromal cells and distributed from the corneal epithelial layer to the stromal layer. IVCM might be useful for the standardization of disease severity by digitalizing the range of deposits. J Korean Ophthalmol Soc 2014;55(3):361-367

키워드

Avellino corneal dystrophy, Confocal microscopy, Z-scan optical pachymeter