망막분지정맥폐쇄에서 황반부종 치료로 유리체강내 베바시주맙 주입술의 장기 효과

• 영문명: Intravitreal Bevacizumab Injection for Macular Edema Secondary to Branch Retinal Vein Occlusion: Long-Term Results
• 발행기관: 대한안과학회
• 저자명: 안성민 이수정 박정민,Seong Min Ahn, MD, Soo Jung Lee, MD, PhD, Jung Min Park, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number3, 379~386쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.03.15

영문 초록

Purpose: To evaluate the long-term results of intravitreal bevacizumab injection for macular edema secondary to branch retinal vein occlusion (BRVO). Methods: Fifty-six eyes with macular edema secondary to BRVO were treated with intravitreal bevacizumab injection. They were classified into two groups, one group that received three initial intravitreal bevacizumab loadings at monthly intervals and a second group that received only one initial injection. In the two groups, additive injection was performed at recurrence. The best corrected visual acuity (BCVA), central macular thickness (CMT) and retinal ischemic change was analyzed for more than 12 months postoperatively. Results: After 12 months of follow-up, mean BCVA improved and mean CMT reduced significantly in both groups (p< 0.05). However, the range of BCVA improvement and CMT reduction was wider in the three-injection group than in the single-injection group. Fluorescein angiography revealed posterior retinal ischemic changes; bevacizumab didn't seem to aggravate the ischemic change. No drug-related ocular or systemic side effects were observed in the follow-up period after intravitreal bevacizumab treatment except subconjunctival hemorrhage and a mild increase of intraocular pressure. Conclusions: In patients with macular edema secondary to BRVO, intravitreal bevacizumab injection was a safe and effective treatment, and a more significant visual improvement and reduction of macular edema was achieved after three initial loadings rather than after a single injection. J Korean Ophthalmol Soc 2014;55(3):379-386

키워드

Bevacizumab, Initial loading, Macular edema, Retinal ischemia, Retinal vein occlusion