후천성 면역 결핍증 환자에서 발생한 각결막의 편평세포암 1예

• 영문명: Clinicopathological Report of Squamous Cell Carcinoma of Conjunctiva and Cornea in a Patient with AIDS
• 발행기관: 대한안과학회
• 저자명: 양민규 김보혁 김미금 위원량 오주연,Min Kyu Yang, MD, Bo Hyuk Kim, MD, Mee Kum Kim, MD, PhD,Won Ryang Wee, MD, PhD, Joo Youn Oh, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number9, 1440~1444쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.09.15

영문 초록

Purpose: To describe the clinical and histopathological findings of corneal and conjunctival squamous cell carcinoma (SCC) in a patient with acquired immune deficiency syndrome (AIDS). Case summary: A 45-year-old Korean male who had been diagnosed of AIDS 20 years before presented with vascularized mass in the inferotemporal conjunctiva and in the cornea. The patient underwent an en bloc excisional biopsy of the mass, application of mitomycin C, and repeated cycles of freeze-thaw. Histopathology revealed dysplastic squamous epithelium in the full thickness of epithelial layer. Immunohistochemical staining for proliferation markers showed that the tumor had a high proliferation index: Ki-67 was positive throughout the full epithelial layer, and both p53 and p16 were positive. The patient had an adjuvant chemotherapy with topical interferon alpha 2b (IFNα 2b) for 8 months after surgery. Conclusions: Given the high proliferation index of the tumor in this patient, close observation and combined adjuvant chemotherapy will be required to prevent recurrence in a patient with AIDS.

키워드

Acquired immune deficiency syndrome, Conjunctiva, Cornea, Squamous cell carcinoma