유리체강내 ganciclovir 주입술을 이용한 거대세포바이러스망막염 치료 2예

• 영문명: Two Cases of Intravitreal Ganciclovir Injection for Cytomegalovirus Retinitis
• 발행기관: 대한안과학회
• 저자명: 한정빈 이승원 곽형우,Jung Bin Han, MD, Seung Won Lee, MD, Hyung Woo Kwak, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number6, 977~981쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.06.15

영문 초록

Purpose: To report 2 cases of cytomegalovirus retinitis treated with intravitreal ganciclovir. Case summary: A 29-year-old female (Case 1) who received immunosuppressive therapy with tacrolimus and mycophenolate mofetil for 3 months after pancreatic transplantation, was given an intravitreal Bevacizumab injection 4 times in each eye under the suspicion of bilateral central retinal vein occlusion. During follow-up, a new lesion with white opacification and multiple snowballs appeared in the left eye. Suspecting cytomegalovirus retinitis, we administered an intravitreal ganciclovir injection resulting in a decrease of white opacification and improvement of visual acuity. A 66-year-old male (Case 2) who was receiving treatment for general weakness and heart failure, presented with visual disturbance in both eyes. Fundoscopic examination revealed white opacification, multiple snowballs and retinal hemorrhage in the left eye; diagnostic vitrectomy was performed. Macular edema and subretinal fluid continued after the vitrectomy and the serologic testing revealed an IgG titer positive for cytomegalovirus, therefore, an intravitreal injection of ganciclovir was given. Macular edema and subretinal fluid decreased and visual acuity improved. Conclusions: Intravitreal ganciclovir can be an effective treatment option for the management of CMV retinitis.

키워드

Cytomegalovirus retinitis, Ganciclovir, Intravitreal ganciclovir injection