전층각막이식술을 받은 5세 이하 환아들의 수술 성적

• 영문명: Clinical Outcomes of Penetrating Keratoplasty in Patients Five Years or Younger
• 발행기관: 대한안과학회
• 저자명: 김용우 최혁진 김미금 위원량 유영석 오주연,Yong Woo Kim, MD, Hyuk Jin Choi, MD,, Mee Kum Kim, MD, Won Ryang Wee, MD,Young Suk Yu, MD, Joo Youn Oh, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number5, 704~708쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.05.15

영문 초록

Purpose: To investigate the clinical outcomes of primary pediatric keratoplasty. Methods: Records of patients who underwent penetrating keratoplasty at the age of 5 years or younger were retrospectively reviewed. The survival rates of corneal grafts, postoperative complications, and causes of graft failure were evaluated. Results: A total of 31 penetrating keratoplasties were performed in 29 patients, two of which were bilateral. The mean follow- up period was 78.72 ± 8.94 months. The overall graft survival rate was 51.61%. The graft survival rate was 77.4% at 6 months, 61.3% at 12 months, 57.5% at 2 years, and 49.5% at 5 years after the surgery (the median survival time, 39.2 months). The main surgical indications included sclerocornea (35.5%), followed by Peter’s anomaly (25.8%) and congenital glaucoma (9.7%). There were significant differences in graft survival time among the surgical indications, of which sclerocornea was the worst (p = 0.003). The main cause of graft failure was rejection (46.7%), followed by infection (26.7%) and primary endothelial decompensation (20%). When patients were sub-grouped according to age (under 12 months, between 12 to 48 months, and over 48 months), there was significant difference in graft survival time (p = 0.037) but not in overall graft survival rate (p = 0.154). Graft rejection occurred more frequently in patients between 12 to 48 months of age compared to other age groups (p = 0.016). Three out of 13 graft infections occurred in patients under 12 months of age. Conclusions: The type of disease causing corneal opacity was a significant factor affecting the clinical outcomes of penetrating keratoplasty in children.

키워드

Graft survival time, Penetrating keratoplasty