전층 각막이식술 후 장기간 경과 시 각막내피세포 생존에 영향을 주는 요인 분석

• 영문명: Analysis of Factors Affecting Corneal Endothelial Cell Loss after Penetrating Keratoplasty
• 발행기관: 대한안과학회
• 저자명: 김태경 변용수 김만수,Tai Kyong Kim, MD, Yong Soo Byun, MD, Man Soo Kim, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume52,number7, 807~815쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.07.15

영문 초록

Purpose: To evaluate the factors affecting corneal endothelial cell loss after penetrating keratoplasty in a long-term follow- up. Methods: Donor age, post-mortem time, storage time, underlying disease, elevation of IOP after surgery, underlying glaucoma, and trephine size were analyzed in 76 eyes. Postoperative corneal endothelial density was measured after 1, 3, 6, and 12 months. Patients who experienced graft rejection were excluded. Results: Donor age and endothelial loss were correlated in all patients (t-value = 1.98); however, post-mortem time and storage time were not statistically significant (t < 2). Endothelial cell loss was more severe in the bullous keratopathy patient group than it was in the keratoconus patient group, but this difference was not statistically significant (p-value = 0.154). The number of anti-glaucomatous eye drops showed positive correlation with the declining rate of endothelial cells (t-value = 1.975). Existence of glaucoma diagnosed before surgery did not statistically influence endothelial cell loss. Additionally, in the bullous keratopathy patient group, an inverse correlation between endothelial cell loss and trephine diameter was observed (t-value = -2.859). Conclusions: Old donor age, small trephine size in bullous keratopathy, and post-operative IOP elevation are risk factors for increased endothelial cell loss following penetrating keratoplasty. J Korean Ophthalmol Soc 2011;52(7):807-815

키워드

Donor age, Endothelial cell, Glaucoma, Penetrating keratoplasty, Trephine diameter