눈주위 트리암시롤론 주사를 이용한 갑상선 안병증의 치료효과

• 영문명: Therapeutic Effects of Periocular Injection of Triamcinolon Acetonide in Patients with Thyroid-Associated Ophthalmopathy
• 발행기관: 대한안과학회
• 저자명: 김종을 박정원 조재갑 윤경철,Jong-Eul Kim, MD, Jung-Won Park, MD, Jae-Kap Cho, MD, Kyung-Chul Yoon, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume52,number7, 788~793쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.07.15

영문 초록

Purpose: The present study investigated the therapeutic effects of periocular triamcinolone acetonide injections to treat inflammatory signs in patients with severe acute thyroid-associated ophthalmopathy. Methods: Twenty-two patients with symptoms of severe acute thyroid ophthalmopathy were enrolled in the present study. The patients received four doses of 20 mg of triamcinolone acetonide via periocular injection into the inferotemporal orbital quadrant every 2 weeks. The changes in visual acuity, intraocular pressure, eye ball motility, exophthalmos, thickness of extraocular muscles, clinical activity score and NOSPECS score were measured. Results: Eighteen of 22 patients (81.8%) showed improvement in soft tissue swelling, ten patients (45.5%) showed improvement in conjunctival hyperemia and one patient showed improvement of ocular motility. Clinical activity score and NOSPECS score had significant improvements. No patient had changes in visual acuity, intraocular pressure, diplopia, proptosis or thickness of extraocular muscles. An ocular adverse effect was found in one patient, who had subcutaneous fat atrophy at the injection site. Conclusions: In patients with severe acute thyroid ophthalmopathy, periocular triamcinolone acetonide injection can be effective to improve acute inflammatory symptoms, without significant adverse effects. J Korean Ophthalmol Soc 2011;52(7):788-793

키워드

Periocular injection, Thyroid-associated ophthalmopathy, Triamcinolone