매우 광범위한 허혈성 증식당뇨망막병증에서 급속히 증식하는 망막전막의 미세구조

• 영문명: Ultrastructure of Rapidly Proliferating Preretinal Membrane of Very Extensive Ischemic Diabetic Retinopathy
• 발행기관: 대한안과학회
• 저자명: 박영숙 한정훈 신용운 전재연 고명규 이병로,Young Sook Park, MD, PhD, Jung Hoon Han, MD, PhD, Yong Un Shin, MD, Jae Yeon Jun, MD, Myung Kyu Ko, MD, PhD, Byung Ro Lee, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume51,number11, 1504~1512쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.11.15

영문 초록

Purpose: Using transmission electron microscopy (TEM), we studied the ultrastructures of rapidly proliferating preretinal membranes of young patients with very extensive ischemic proliferative diabetic retinopathy and diabetes with uncontrollable blood sugar level. Methods: Nine cases of preretinal membranes were obtained from six eyes of five patients with rapidly progressed proliferative diabetic retinopathy (mean age, 35 years) during vitrectomy. We obtained each preretinal membrane bimanually as one single sheet membrane using intraocular scissors and forceps. Each tissue was fixed in 3% glutaraldehyde in the operating room. All specimens were prepared and studied using TEM. Results: The preretinal membranes were composed of blood vessels and some interstitial cells. The blood vessels within the preretinal membranes varied in developmental stages, from the immature stage to the mature stage. The blood vessels were highly active, in that primitive cells showed a large nucleus and prominent chromatin clumping with abundant cytoplasm. Highly active fibroblast-like cells were also noted. Conclusions: We observed highly active angiogenesis in preretinal membranes, which rapidly proliferated in cases of severe retinal ischemia in young diabetes patients. This is the first report of such a finding, which may help to explain the poor prognosis of this disease modality. J Korean Ophthalmol Soc 2010;51(11):1504-1512

키워드

Capillary nonperfusion, Diabetic retinopathy, Preretinal membrane, Transmission electron microscopy