베바시주맙이 섬유주세포의 생존과 일산화질소의 생성에 미치는 영향

• 영문명: Effect of Bevacizumab on Survival and Production of Nitric Oxide in Trabecular Meshwork Cells
• 발행기관: 대한안과학회
• 저자명: 김신후 김재우,Sin Hoo Kim, MD, Jae Woo Kim, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume50,number9, 1404~1408쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.09.15

영문 초록

Purpose: To investigate the effect of bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), on the survival and production of nitric oxide (NO) in human trabecular meshwork cells (HTMC). Methods: Primarily cultured HTMC were exposed to 0, 0.25, 1.0, and 2.5 mg/ml bevacizumab for 24 hours. Cellular survival and production of NO were assessed by MTT assay and Griess assay, respectively. Results: Bevacizumab did not affect the cellular survival at low concentrations but decreased cellular survival significantly at high concentrations (>1.0 mg/ml) accompanied with increased NO production. Conclusions: High concentrations of bevacizumab may be toxic to HTMC.

키워드

Bevacizumab, Nitric oxide, Trabecular meshwork cells