후천성면역결핍증후군 환자에서 발생한 Rifabutin에 의한 포도막염 1예

• 영문명: Rifabutin Related Uveitis in AIDS: A Case Report
• 발행기관: 대한안과학회
• 저자명: 박용출 이지웅 신재필 김시열,Yong Chul Park, MD, Ji Woong Lee, MD, Jae Pil Shin, MD, Si Yeol Kim, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume50,number6, 951~956쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.06.15

영문 초록

Purpose: To describe a case of symptomatic rifabutin-related uveitis with hypopyon and vitreous opacity in apatient with acquired immunodeficiency syndrome infected with Mycobacterium tuberculosis. Case summary: A 33-year-old male patient with acquired immunodeficiency syndrome was referred to our clinic for abruptly decreased vision in his right eye. Multi-drug therapy with rifabutin was administered for 5 weeks to treat tuberculosis enteritis and pulmonary tuberculosis. Visual acuity of the right eye was hand motion and hypopyon as well as vitreous opacity was found in ocular examinations. Other serologic tests, anterior chamber paracentesis and lumbar puncture test were normal. Rifabutin was immediately stopped and topical steroid and cycloplegics were administered, which resulted in resolution of the hypopyon, vitreous opacity and visual acuity. Four weeks after the initial episode, rifabutin was restarted to treat the pulmonary tuberculosis and rifabutin-related uveitis relapsed in the opposite eye. Conclusions: Rifabutin-related uveitis should be considered in cases of uveitis in immunosuppressive patients, especially in acquired immunodeficiency syndrome patients. Underlying disease and medication history should be carefully assessed.

키워드

Acquired immunodeficiency syndrome, Rifabutin, Uveitis