메타졸라마이드 복용 후 발생한 스티븐스-존슨 증후군

• 영문명: Methazolamide-induced Stevens-Johnson Syndrome
• 발행기관: 대한안과학회
• 저자명: 서영승 장기철 장무환,Young Seung Seo, MD, Ki Cheol Chang, MD, Moo Hwan Chang, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume50,number12, 1881~1886쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.12.15

영문 초록

Purpose: To report three consecutive cases of methazolamide-induced Stevens-Johnson syndrome. Case summary: We describe three patients who were all prescribed methazolamide for treatment of ophthalmologic conditions. A 29-year-old man and a 47- year-old woman were prescribed methazolamide (100 mg/day) for the treatment of central serous chorioretinopathy (CSCR). A 66-year-old woman was prescribed methazolamide (100 mg/day) for acute glaucoma of the left eye for approximately two weeks. After taking the methazolamide, three patients were showed the pururitic maculopapular rashes on the whole body and the vesicular eruptions of the oral mucosa and conjunctiva. On the basis of medication histories, characteristic skin lesions and mucosal involvement, we diagnosed all three patients with methazolamide-induced Stevens-Johnson syndrome. All three patients were hospitalized and treated with intravenous steroids and antihistamines. Two of the three cases showed conjunctival pseudomembranes. In two cases, the skin lesions worsened during the first week of treatment, and then resolved without complications over the next two to three weeks. The condition of the 47-year-old female patient deteriorated rapidly to toxic epidermal necrolysis due to sensitivity to sulfa antibiotics. HLA- A24, B59 and Cw1 were detected in all three cases. Conclusions: In 2008, domestic production of acetazolamide was halted in Korea. Because of this, methazolamide is expected to be prescribed by ophthalmologists more commonly than in previous years. Complete medical histories should be taken before prescribing methazolamide to patients. HLA typing should be conducted whenever possible to screen patients before prescription of methazolamide. J Korean Ophthalmol Soc 2009;50(12):1881-1886

키워드

HLA B59, Methazolamide, Stevens-Johnson syndrome