가토에서 버테포르핀을 이용한 각막신생혈관의 광역학치료시 재치료의 효과

• 영문명: The Effect of Photodynamic Therapy with Verteporfin Retreatment on Corneal Neovascularization in Rabbits
• 발행기관: 대한안과학회
• 저자명: 전은정 노영정 김영훈 정성근,Eun Jung Jun, M.D., Young Jung Rho, M.D., Yeong Hoon Kim, M.D., Sung Kun Chung, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume49,number9, 1515~1524쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.09.15

영문 초록

Purpose: This study evaluated the effect and safety of photodynamic therapy (PDT) with verteporfin retreatment on patients with corneal neovascularization. Methods: Corneal neovascularization was induced with a silk suture of the corneal stroma in 24 white rabbits (48 eyes). Four rabbits were examined histologically before performing PDT. Ten rabbits were chosen randomly, one eye from each rabbit was treated with PDT at 50 J/cm2, and the other eye was used as a control. Both eyes of the remaining 10 rabbits were treated with PDT at 150 J/cm2. One week later, one eye was further retreated with PDT at the same intensity. The area of corneal neovascularization was measured and evaluated histologically using light and electron microscopies. Results: The least neovascularized area was observed in the retreated group (P=0.04). The histologic examination revealed fewer new corneal vessels in the retreated group, but the corneal epithelium, stroma, and endothelium showed a normal appearance. Results from electron microscopic examination demonstrated thrombi as well as destruction and nuclear fragmentation of the vascular endothelial cells. However, there were no other changes in the cornea except for vascular endothelial cells, even in the retreated group. Conclusions: In conclusion, these results suggest that PDT with verteporfin retreatment appears to be safe and significantly more effective in patients with regression of corneal neovascularization. J Korean Ophthalmol Soc 2008;49(9):1515-1524

키워드

Cornea, Neovascularization, Photodynamic therapy (PDT), Retreatment, Verteporfin