인체 백혈구 항원-B27 연관 앞포도막염 환자의 방수 내 키모카인 및 키모카인 수용체 분석

• 영문명: Analysis of Intraocular Chemokine and Chemokine Receptor in Patients with HLA-B27-associated Anterior Uveitis
• 발행기관: 대한안과학회
• 저자명: 김태완 정흠 유형곤 ,Tae Wan Kim, M.D.,,, Hum Chung, M.D., Ph.D., Hyeong Gon Yu, M.D., Ph.D,
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume49,number9, 1475~1482쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.09.15

영문 초록

Purpose: To evaluate the expression of chemokine and chemokine receptors in the aqueous humor (AH) of patients with recurrent anterior uveitis (AU) in terms of HLA-B-27-association. Methods: Patients with endogenous uveitis were recruited from the uveitis clinic at Seoul National University Hospital. AH and peripheral blood (PB) were obtained from each patient. The expression of chemokine receptors in T-cells from AH and PB was measured using flow cytometric analysis. Interleukin (IL)-8, interferon-γinducible protein (IP)-10, and regulated-on-expression, normal T-cell expressed and secreted (RANTES) levels of PB and AH were measured. The expression of chemokine receptor and chemokine levels in PB and AH were compared between HLA-B27-associated AU and idiopathic AU patients. Results: Seventeen patients with HLA-B27-associated AU, 14 patients with idiopathic AU and 5 healthy controls were included in this study. IL-8 and IP-10 levels of AH were shown to be increased more than in PB, and intraocular concentrations of IL-8 and IP-10 were higher in patients with HLA-B27-associated AU than in idiopathic AU patients. RANTES levels in AH were significantly lower than in PB for all groups. In all groups, the expression of chemokine receptor in AH increased more than in PB. Conclusions: The results from this study show chemokine may play an important role in inflammation in patients with AU. This implies that the chemokine environment may be different in terms of HLA-B-27-association. J Korean Ophthalmol Soc 2008;49(9):1475-1482

키워드

Chemokine, Chemokine receptor, HLA-B27-associated anterior uveitis