망막분지정맥폐쇄에서 유리체강내 트리암시놀론 주사 후 방수내 혈관투과인자들의 변화

• 영문명: The Changes of Aqueous Vasopermeability Factors After Intravitreal Triamcinolone Injection for Branch Retinal Vein Occlusion
• 발행기관: 대한안과학회
• 저자명: 송승 박성표 안재균,Seung Song, M.D., Sung Pyo Park, M.D., Jae Kyoun Ahn, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume49,number11, 1765~1770쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.11.15

영문 초록

Purpose: To investigate the changes of aqueous vascular endothelial growth factor (VEGF) and interleukin (IL)-6 in patients with acute macular edema secondary to recent-onset branch retinal vein occlusion (BRVO) after a single intravitreal injection of triamcinolone acetonide (IVTA) Methods: Aqueous and plasma levels of VEGF and IL-6 were measured by ELISA in ten controls and thirty patients at the time of IVTA and 3 months afterward. We compared the aqueous levels of VEGF and IL-6 and the clinical course between responders and non-responders. Results: The aqueous levels of VEGF and IL-6 were significantly higher in non-responders than in responders at baseline measurements (495±259 pg/ml vs. 223±110 pg/ml, P<.001; 36±32 pg/ml vs. 16±19 pg/ml, P=.037, respectively). The aqueous levels of VEGF were still higher in non-responders (303±75 pg/ml) 3 months after IVTA, while the aqueous levels of VEGF in responders returned to normal (77±23 pg/ml, P<.001). The aqueous levels of IL-6 normalized in all patients 3 months after IVTA. In non-responders, central foveal thickness was significantly higher, and foveal ischemia and a wide non-perfused area were more common. Conclusions: Non-IL6-dependent VEGF may contribute to persistent or recurrent ischemic macular edema associated with BRVO after IVTA. J Korean Ophthalmol Soc 2008;49(11):1765-1770

키워드

Branch retinal vein occlusion, Interleukin-6, Intravitreal triamcinolone injection, Ischemic macular edema, Vascular endothelial growth factor