흰쥐에서 경부 교감신경절제술이 안압의 일차변동에 미치는 영향

• 영문명: The Effect of Sympathectomy on Circardian Rhythm of Intraocular Pressure in Rat
• 발행기관: 대한안과학회
• 저자명: 임남기 김태형 송준경 유지명,Nam Kee Lim, M.D., Tae Hyung Kim, M.D., Joon Kyeong Song, M.D., Ji Myong Yoo, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume49,number11, 1839~1844쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.11.15

영문 초록

Purpose: The present study was undertaken to determine the 24-hour pattern of intraocular pressure (IOP), and to reveal the effect of unilateral decentralization on circardian rhythm of IOP in eyes of rats. Methods: Nine male Sprague-Dawley rats were exposed to a 12-hour light/dark cycle for 3 weeks. 24-hours IOP pattern was measured at six time points (8, 12, 16, 20, 24, and 4 circardian time) by Tonopen XL tonometer in awake state. After unilateral sympathectomy (cervical ganglionectomy), IOP measurements were performed at the same time points on post-operation 1, 2, 3, and 4 weeks. Results: 24-hour IOP pattern of rats showed a rhythmic pattern that appeared to be sinusoidal with 12-hour light/dark cycle. IOPs were low during the light phase and high during dark phase. After unilateral sympathectomy, the circardian rhythm of IOP was maintained in control eyes. But in sympathecotmized eyes, the circardian thythm of IOP was loss. Conclusions: These results show that sympathetic nervous systems contribute to the circardian rhythm of IOP in rats. J Korean Ophthalmol Soc 2008;49(11):1839-1844

키워드

Circardian rhythm, Intraocular pressure, Sympathectomy