원인미상의 윤부염을 동반한 T-세포 매개 만성 결막염을 경구 사이클로스포린으로 완치한 1예

• 영문명: A Case of Idiopathic T-cell Mediated Chronic Conjunctivitis With Limbitis Treated Using Oral Cyclosporine
• 발행기관: 대한안과학회
• 저자명: 박정현 위원량 이진학 김미금,ung Hyun Park, M.D., Won Ryang Wee, M.D., Ph.D.,, Jin Hak Lee, M.D. Ph.D.,, Mee Kum Kim, M.D., Ph.D.,
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume48,number11, 1567~1572쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.11.30

영문 초록

Purpose: To report a case of refractory idiopathic T cell mediated chronic conjunctivitis causing limbal insufficiency, which improved with cyclosporine therapy. Case Summary: A 43-year old man complained of conjunctival injection and discomfort in both eyes that lasted three years and was refractory to topical steroids, antibiotics, and artificial tears. There was no evidence of connective tissue diseases, Stevens-Johnson syndrome, pemphigoid, or drug history. Both eyes presented with diffuse injection and thickening of the conjunctiva, punctuated epithelial erosion of the conjunctiva and cornea, severe limbal epithelitis and elevated intraocular pressure. The left cornea was conjunctivalized due to limbal deficiency. Histological examination revealed severe infiltration of T and B cells, without any evidence of tumor cells or basement membrane anomaly. When treated with oral cyclosporine, injection and thickening of the conjunctiva decreased and the intraocular pressure was normalized. The surface inflammation of both eyes completely resolved two months after the treatment was initiated. Conclusions: In chronic idiopathic conjunctivitis with limbitis resistant to conventional treatment and T cell infiltration found in pathological examination, oral cyclosporine therapy might be required to resolve inflammation.

키워드

Conjunctivitis, Limbitis, Cyclosporine, T cell