트리암시놀론 아세토나이드의 유리체강내 주사 농도에 따른 유리체강내의 잔류 기간 및 제거율 변화

• 영문명: Change of Residual Period and Clearance Rate of Intravitreal Triamcinolone According to Initial Injection Dosage
• 발행기관: 대한안과학회
• 저자명: 김태환 문연성 진희승,Tae-Hwan Kim, M.D., Yeon-Sung Moon, M.D., Hee-Seung Chin, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume46,number9, 1569~1574쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.09.30

영문 초록

Purpose: We sought to determine how the initial concentration of triamcinolone acetonide injected intravitreally might influence the clearance and residual period of the intravitreal triamcinolone acetonide. Methods: Sixty-four eyes of 32 rabbits were divided into 4 groups. Each group was injected with 5, 10, 15, or 20 mg/0.1 ml of triamcinolone acetonide intravitreally. At 1, 7, 14, and 28 days after intravitreal injection, four eyes were obtained from each group by sacrificing two rabbits. The vitreous bodies were obtained and prepared for HPLC analysis. The concentrations of triamcinolone acetonide were quantitated by HPLC with fluorescence detector. We compared the data using the logarithmic regression coefficients of each line. Results: The elimination half-lives of the intravitreal triamcinolone acetonide were 3.23 days, 3.73 days, 4.11 days, and 4.98 days at the initial injection doses of 5, 10, 15, and 20 mg per 0.1 ml, respectively. Compared to the 5 mg initial dose, the clearance rate of the intravitreal triamcinolone acetonide was decreased 1.15 times, 1.27 times and 1.55 times at 10 mg, 15 mg, and 20 mg of the initial dose, respectively. Conclusions: The residual duration of intravitreal triamcinolone acetonide was prolonged as the initial concentration of intravitreal injection increased. Furthermore, the clearance rate decreased as the injection dose is increased. This shows that higher injection doses of triamcinolone acetonide induce not only an increased intravitreal concentration, but also prolonged the duration of effectiveness.

키워드

Clearance rate, Intravitreal injection, Residual period, Triamcinolone acetonide