호장으로부터 분리한 안트라퀴논류의 Nitric Oxide 저해활성

• 영문명: Inhibition of Nitric Oxide Production by Anthraquinones from Polygonum cuspidatum
• 발행기관: 대한약학회
• 저자명: 주시몽(Si Mong Joo) 양기숙(Ki Sook Yang)
• 간행물 정보: 『약학회지』제54권 제5호 (2010년), 387~391쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.10.31

영문 초록

Polygonum cuspidatum which is widely distributed in Korea has been used as treatments of dermatitis, gonorrhea and inflammation in traditional medicine. We examined anti-inflammatory activities by the inhibition of NO production in RAW264.7 murine macrophages cells. Phytochemical examination of Polygonum cuspidatum led to the isolation and characterization of emodin (1), emodin 8-O-β-D-glucopyranoside (2), emodin 1-O-β-D-glucopyranoside (3). Antioxidative activities of these compounds were determined by measuring the radical scavenging effects on DPPH radicals. Compounds 1 and 3 showed potent activities compared with L-NMMA. These results suggested that the antraquinone compounds isolated from Polygonum cuspidatum might be used as antiinflammatory agents.

키워드

Polygonum cuspidatum emodin emodin 8-O-β-D-glucopyranoside emodin 1-O-β-D-glucopyranoside antiinflammatory agents