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• 영문명: Preparation of Amorphous Adefovir dipivoxil using Reverse Phase Column Chromatography and Solid Dispersion Method
• 발행기관: 대한약학회
• 저자명: 윤명식(Myeong Sik Yoon) 오다원(Da Won Oh) 맹효찬(Hyo Chan Maeng) 홍혜숙(Hye Suk Hong) 박미경(Mi Kyung Park) 이용택(Yong Tack Lee) 이시범(Si Beum Lee) 조일환(Il Hwan Cho) 문병석(Byoung Seok Moon)
• 간행물 정보: 『약학회지』제54권 제4호 (2010년), 316~321쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.08.31

영문 초록

Adefovir dipivoxil which was originally developed by Gilead Sciences has been used as treatments of HIV and HBV, especially a therapeutics for HBeAg positive and negative chronic patients. We developed highly efficient purification method using reverse phase column chromatography for mass production and a stable amorphous Adefovir dipivoxil using solid dispersion method. Reverse phase column chromatography led to highly pure product, more than 99.7% by HPLC and can be used for mass production compared with normal column chromatography. Solid dispersion method containing watersoluble polymer and Isomalt showed improved stability of amorphous Adefovir dipivoxil against heat and moisture.

키워드

Adefovir dipivoxil reverse phase column chromatography solid dispersion amorphous purification mass production