간보호 효과를 나타내는 Isowogonin의 전합성 및 Wogonin 합성을 위한 반응조건 탐색

• 영문명: Total Synthesis of Hepatoprotective Isowogonin and a Synthetic Approach to Wogonin
• 발행기관: 대한약학회
• 저자명: 김광식(Kwangsik Kim) 김학성(Hak Sung Kim)
• 간행물 정보: 『약학회지』제53권 제6호 (2009년), 377~381쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.12.31

영문 초록

Isowogonin, 5,8-dihydroxy-7-methoxyflavone, is a flavonoid isolated from the root of Scutellaria baicalensis Georgi, a medicinal plant traditionally used since the ancient time. It was thought to possess a variety of biological activities, such as antioxidation, anti-inflammation and hepatoprotective effect. But a quantity of isowogonin obtained from Scutellaria baicalensis Georgi is not that enough for in vivo test. There have been no appropriate approaches available for a facile synthesis of isowogonin. So we describe a concise and efficient scheme for synthesis of isowogonin from a commercial available 2,4,6-trimethoxyphenol, which includes the Fries rearrangement and selective demethylation as key steps.

키워드

isowogonin Fries rearrangement selective protection selective demethylation