Licochalcone A가 대식세포주의 사이토카인 생성에 미치는 영향

• 영문명: Effect of Licochalcone A on the Production of Cytokines in LPS-Activated RAW264.7 Macrophage Cells
• 발행기관: 대한약학회
• 저자명: 이기세(Gi-Sae Lee) 천승훈(Seung Hoon Cheon) 이성호(Sung Ho Lee) 강복윤(Bok Yun Kang) 조영창(Young-Chang Cho) 윤구(Goo Yoon)
• 간행물 정보: 『약학회지』제53권 제6호 (2009년), 321~327쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.12.31

영문 초록

Licochalcone A is a chalcone isolated from the roots of Glycyrrhiza inflate. In this study, we examined the effects of licochalonce A on the production of cytokines in LPS-activated macrophages. Licochalcone A inhibited the secretion of proinflammatory cytokines such as IL-1β IL-6, and TNF-? The reduced secretion of proinflammatory cytokines is related to the differences in the mRNA expression of IL-1β IL-6, and TNF-α Moreover, licochalcone A inhibited the mRNA expression of IL-12p40, IL-18, and IL-23p19. To investigate its mechanism, we performed gel shift assay. Licochalcone A reduced nuclear NF-kB binding activity in LPS-activated RAW264.7 cells. Taken together, these results suggest that licochalcone A has anti-inflammatory effects in LPS-activated macrophages and its mechanism could be through the down-regulation of binding to the kB site.

키워드

licochalcone A macrophage inflammation cytokines