Dexamethasone에 의한 RANKL 유도성 파골세포 분화 촉진 효과

• 영문명: The Stimulatory Effect of Dexamethasone on RANKL-induced Osteoclastogenesis
• 발행기관: 대한약학회
• 저자명: 노아롱새미(A Long Sae Mi No) 천링(Ling Chen) 박효정(Hyojung Park) 양미혜(Mihye Yang) 이정민(Jung Min Lee) 임미정(Mijung Yim)
• 간행물 정보: 『약학회지』제53권 제2호 (2009년), 78~82쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.04.30

영문 초록

We explored the effects of dexamethasone on osteoclast precursors using BMMs. Dexamethasone inhibited the proliferation of BMMs. Furthermore, it stimulated the osteoclast formation via NFATc1 activation in the presence of RANKL. Since dexamethasone targeted the early stage of osteoclast formation, we investigated its effect on mRNA expression of GR and IFN-β. Whereas dexamethasone had no effects on GR expression in the presence of RANKL, it reduced he expression of IFN-β, suggesting that dexamethasone increased RANKL-induced osteoclast formation by modulating IFN-β.

키워드

glucocorticoid dexamethasone osteoclast IFN-β