마우스 간의 황함유 아미노산 대사에 미치는 베타인의 용량의존성 영향

• 영문명: Dose-dependent Effects of Betaine on Hepatic Metabolism of Sulfur Amino Acids in Mice
• 발행기관: 대한약학회
• 저자명: 김상겸(Sang Kyum Kim)
• 간행물 정보: 『약학회지』제53권 제2호 (2009년), 69~73쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.04.30

영문 초록

Acute betaine treatment induces time-dependent changes in the hepatic glutathione (GSH), cysteine and Sadenosylmethionine (SAM) levels. Our previous study demonstrated that betaine administered 1~4 hours prior to sacrifice decreased hepatic GSH levels, but these levels were increased when measured 24 hours following the treatment. The present study was aimed to determine dose-dependent effects of betaine on hepatic metabolism of sulfur amino acid in mice. Mice were sacrificed 2.5 or 24 hours after intraperitoneal treatment with betaine at different dose levels ranging from 50 to 1000 mg/kg. The concentrations of methionine and SAM were increased by a betaine dose of 100 mg/kg, and the concentrations of GSH and cysteine were decreased by a betaine dose of 200 mg/kg at 2.5 hours. These changes were augmented with increasing doses of betaine. At 24 hours following betaine treatment, increased GSH and decreased taurine levels were observed from dose levels of 400 mg/kg. Changes in hepatic activities of cystathionine beta-synthase, gammaglutamylcysteine ligase and cysteine dioxygenase were observed from dose levels of 200~400 mg/kg of betaine administered 24 hours prior to sacrifice.

키워드

betaine sulfur amino acid hepatic metabolism transsulfuration