녹차추출물/L-Theanine 혼합물의 Secretase 활성 억제 및 세포사 억제를 통한 기억력 회복능

• 영문명: Improvement of Memory Impairment of Green Tea Extract/L-Theanine Through Inhibition of Secretase Activity and Cell Death In Vivo
• 발행기관: 대한약학회
• 저자명: 김태일(Tae Il Kim) 육동연(Dong Yeon Yuk) 박상기(Sang Ki Park) 박형국(Hyoung Kook Park) 윤여경(Yeo Kyeung Yoon) 홍진태(Jin Tae Hong)
• 간행물 정보: 『약학회지』제52권 제5호 (2008년), 384~393쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.10.31

영문 초록

We examined the effect of green tea extract (GTE) and L-theanine combination on the Aβ1-42-induced memory dysfunction. GTE and combination were administrated into mice for 3 weeks followed by injection of Aβ1-42 to induce memory impairment. GTE and L-theanine administration significantly improved cognitive ability and reduced Aβ1-42 level accompanied with the inhibition of neuronal cell death and activities of secretase. These results suggest that GTE and L-theanine combination may be a useful for preventing for the development or progression of Alzheimer’s disease.

키워드

green tea extract L-theanine Alzheimer's disease memory secretase amyloid beta cell death