벤조산 유도체의 Chromium Trioxide 독성에 대한 세포 재생효과

• 영문명: The Cell Regenerative Effect of Benzoic Acid Derivatives Against Chomium Trioxide-Induced Cytotoxicity
• 발행기관: 대한약학회
• 저자명: 한두석(Du Seok Han) 최병남(Byung Nam Choi) 이재숙(Jae Sug Lee) 최화정(Hwa Jung Choi) 백승화(Seung Hwa Baek)
• 간행물 정보: 『약학회지』제52권 제5호 (2008년), 361~369쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.10.31

영문 초록

In order to evaluate the cytotoxicity of chromium trioxide, and the cell regenerative effect of phenolic acid against chromium trioxide-induced cytotoxicity, cell viability, cell adhesion activity, lactate dehydrogenase (LDH) activity, and morphological changes of cells were performed in these cultures. The toxicity of chromium trioxide (IC50, 44.0 μM) was high according to the toxic criteria. Cell regeneration of benzoic acid derivatives against IC50 value of chromium trioxide in cell morphology was increased in concentration-dependent manner. These results suggest that benzoic acid derivatives may be used as a cell regenerative agent against chromium-ediated cytotoxicity.

키워드

inhibitory effect nickel-mediated cytotoxicity cell viability cell adhesion activty